The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine

Andrew J. McGeehan, Michael Olive

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The effects of the anti-relapse compound acamprosate (calcium acetylhomotaurinate) on the conditioned rewarding effects of ethanol, cocaine and morphine were studied using the conditioned place preference (CPP) paradigm. During 3 days of drug conditioning, mice were pretreated with saline or acamprosate (30, 100 or 300 mg kg -1 i.p.) 10 min prior to the administration of ethanol (2 g kg -1 i.p.), cocaine (15 mg kg -1 i.p.) or morphine (10 mg kg -1 i.p.), and subsequently confined to one of two distinct conditioning chambers. On the following day, mice were tested for the expression of CPP. Acamprosate dose-dependently reduced the development of CPP to ethanol and cocaine but not morphine. When tested as the conditioning drug, acamprosate alone produced neither a conditioned place preference nor aversion. These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalBritish Journal of Pharmacology
Volume138
Issue number1
DOIs
StatePublished - Jan 2003
Externally publishedYes

Fingerprint

Cocaine
Morphine
Ethanol
Recurrence
Pharmaceutical Preparations
acamprosate

Keywords

  • Acamprosate
  • Cocaine
  • Conditioned place preference
  • Ethanol
  • Glutamate
  • Morphine
  • NMDA
  • Reward

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{2b71a5547bd442478d6dee342808512e,
title = "The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine",
abstract = "The effects of the anti-relapse compound acamprosate (calcium acetylhomotaurinate) on the conditioned rewarding effects of ethanol, cocaine and morphine were studied using the conditioned place preference (CPP) paradigm. During 3 days of drug conditioning, mice were pretreated with saline or acamprosate (30, 100 or 300 mg kg -1 i.p.) 10 min prior to the administration of ethanol (2 g kg -1 i.p.), cocaine (15 mg kg -1 i.p.) or morphine (10 mg kg -1 i.p.), and subsequently confined to one of two distinct conditioning chambers. On the following day, mice were tested for the expression of CPP. Acamprosate dose-dependently reduced the development of CPP to ethanol and cocaine but not morphine. When tested as the conditioning drug, acamprosate alone produced neither a conditioned place preference nor aversion. These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances.",
keywords = "Acamprosate, Cocaine, Conditioned place preference, Ethanol, Glutamate, Morphine, NMDA, Reward",
author = "McGeehan, {Andrew J.} and Michael Olive",
year = "2003",
month = "1",
doi = "10.1038/sj.bjp.0705059",
language = "English (US)",
volume = "138",
pages = "9--12",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine

AU - McGeehan, Andrew J.

AU - Olive, Michael

PY - 2003/1

Y1 - 2003/1

N2 - The effects of the anti-relapse compound acamprosate (calcium acetylhomotaurinate) on the conditioned rewarding effects of ethanol, cocaine and morphine were studied using the conditioned place preference (CPP) paradigm. During 3 days of drug conditioning, mice were pretreated with saline or acamprosate (30, 100 or 300 mg kg -1 i.p.) 10 min prior to the administration of ethanol (2 g kg -1 i.p.), cocaine (15 mg kg -1 i.p.) or morphine (10 mg kg -1 i.p.), and subsequently confined to one of two distinct conditioning chambers. On the following day, mice were tested for the expression of CPP. Acamprosate dose-dependently reduced the development of CPP to ethanol and cocaine but not morphine. When tested as the conditioning drug, acamprosate alone produced neither a conditioned place preference nor aversion. These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances.

AB - The effects of the anti-relapse compound acamprosate (calcium acetylhomotaurinate) on the conditioned rewarding effects of ethanol, cocaine and morphine were studied using the conditioned place preference (CPP) paradigm. During 3 days of drug conditioning, mice were pretreated with saline or acamprosate (30, 100 or 300 mg kg -1 i.p.) 10 min prior to the administration of ethanol (2 g kg -1 i.p.), cocaine (15 mg kg -1 i.p.) or morphine (10 mg kg -1 i.p.), and subsequently confined to one of two distinct conditioning chambers. On the following day, mice were tested for the expression of CPP. Acamprosate dose-dependently reduced the development of CPP to ethanol and cocaine but not morphine. When tested as the conditioning drug, acamprosate alone produced neither a conditioned place preference nor aversion. These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances.

KW - Acamprosate

KW - Cocaine

KW - Conditioned place preference

KW - Ethanol

KW - Glutamate

KW - Morphine

KW - NMDA

KW - Reward

UR - http://www.scopus.com/inward/record.url?scp=0037275407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037275407&partnerID=8YFLogxK

U2 - 10.1038/sj.bjp.0705059

DO - 10.1038/sj.bjp.0705059

M3 - Article

C2 - 12522067

AN - SCOPUS:0037275407

VL - 138

SP - 9

EP - 12

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 1

ER -