Abstract
The effects of the anti-relapse compound acamprosate (calcium acetylhomotaurinate) on the conditioned rewarding effects of ethanol, cocaine and morphine were studied using the conditioned place preference (CPP) paradigm. During 3 days of drug conditioning, mice were pretreated with saline or acamprosate (30, 100 or 300 mg kg -1 i.p.) 10 min prior to the administration of ethanol (2 g kg -1 i.p.), cocaine (15 mg kg -1 i.p.) or morphine (10 mg kg -1 i.p.), and subsequently confined to one of two distinct conditioning chambers. On the following day, mice were tested for the expression of CPP. Acamprosate dose-dependently reduced the development of CPP to ethanol and cocaine but not morphine. When tested as the conditioning drug, acamprosate alone produced neither a conditioned place preference nor aversion. These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances.
Original language | English (US) |
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Pages (from-to) | 9-12 |
Number of pages | 4 |
Journal | British Journal of Pharmacology |
Volume | 138 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2003 |
Externally published | Yes |
Keywords
- Acamprosate
- Cocaine
- Conditioned place preference
- Ethanol
- Glutamate
- Morphine
- NMDA
- Reward
ASJC Scopus subject areas
- Pharmacology