The altered evolutionary trajectories of gene duplicates

Michael Lynch, Vaishali Katju

Research output: Contribution to journalArticle

223 Scopus citations


Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same as those exhibited by well-established paralogs en route to the origin of new beneficial features. Thus, although recent genome-wide analyses have revealed striking patterns of protein-sequence divergence among the members of surviving paralogous gene families, the mechanisms responsible for the historical development of these patterns remain unclear.

Original languageEnglish (US)
Pages (from-to)544-549
Number of pages6
JournalTrends in Genetics
Issue number11
StatePublished - Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'The altered evolutionary trajectories of gene duplicates'. Together they form a unique fingerprint.

  • Cite this