Abstract
Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same as those exhibited by well-established paralogs en route to the origin of new beneficial features. Thus, although recent genome-wide analyses have revealed striking patterns of protein-sequence divergence among the members of surviving paralogous gene families, the mechanisms responsible for the historical development of these patterns remain unclear.
Original language | English (US) |
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Pages (from-to) | 544-549 |
Number of pages | 6 |
Journal | Trends in Genetics |
Volume | 20 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics