The altered evolutionary trajectories of gene duplicates

Michael Lynch, Vaishali Katju

Research output: Contribution to journalReview article

221 Citations (Scopus)

Abstract

Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same as those exhibited by well-established paralogs en route to the origin of new beneficial features. Thus, although recent genome-wide analyses have revealed striking patterns of protein-sequence divergence among the members of surviving paralogous gene families, the mechanisms responsible for the historical development of these patterns remain unclear.

Original languageEnglish (US)
Pages (from-to)544-549
Number of pages6
JournalTrends in Genetics
Volume20
Issue number11
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

Fingerprint

Duplicate Genes
Gene Duplication
Population Genetics
Genes
Genome
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

The altered evolutionary trajectories of gene duplicates. / Lynch, Michael; Katju, Vaishali.

In: Trends in Genetics, Vol. 20, No. 11, 01.11.2004, p. 544-549.

Research output: Contribution to journalReview article

Lynch, Michael ; Katju, Vaishali. / The altered evolutionary trajectories of gene duplicates. In: Trends in Genetics. 2004 ; Vol. 20, No. 11. pp. 544-549.
@article{bd92e457b0d942a2bcd528946e3aca8e,
title = "The altered evolutionary trajectories of gene duplicates",
abstract = "Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same as those exhibited by well-established paralogs en route to the origin of new beneficial features. Thus, although recent genome-wide analyses have revealed striking patterns of protein-sequence divergence among the members of surviving paralogous gene families, the mechanisms responsible for the historical development of these patterns remain unclear.",
author = "Michael Lynch and Vaishali Katju",
year = "2004",
month = "11",
day = "1",
doi = "10.1016/j.tig.2004.09.001",
language = "English (US)",
volume = "20",
pages = "544--549",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - The altered evolutionary trajectories of gene duplicates

AU - Lynch, Michael

AU - Katju, Vaishali

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same as those exhibited by well-established paralogs en route to the origin of new beneficial features. Thus, although recent genome-wide analyses have revealed striking patterns of protein-sequence divergence among the members of surviving paralogous gene families, the mechanisms responsible for the historical development of these patterns remain unclear.

AB - Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same as those exhibited by well-established paralogs en route to the origin of new beneficial features. Thus, although recent genome-wide analyses have revealed striking patterns of protein-sequence divergence among the members of surviving paralogous gene families, the mechanisms responsible for the historical development of these patterns remain unclear.

UR - http://www.scopus.com/inward/record.url?scp=4744343021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4744343021&partnerID=8YFLogxK

U2 - 10.1016/j.tig.2004.09.001

DO - 10.1016/j.tig.2004.09.001

M3 - Review article

C2 - 15475113

AN - SCOPUS:4744343021

VL - 20

SP - 544

EP - 549

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 11

ER -