Abstract
As originally postulated in Crick's Adaptor hypothesis, the faithful synthesis of proteins from messenger RNA is dependent on the presence of perfectly acylated tRNAs. The hypothesis also suggested that each aminoacyl-tRNA would be made by a unique enzyme. Recent data have now forced a revision of this latter point, with an increasingly diverse array of enzymes and pathways being implicated in aminoacyl-tRNA synthesis. These unexpected findings have far-reaching implications for our understanding of protein synthesis and its origins. Copyright (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 311-316 |
Number of pages | 6 |
Journal | Trends in Biochemical Sciences |
Volume | 25 |
Issue number | 7 |
DOIs |
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State | Published - Jul 1 2000 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology