The A beta 6w302 gene and molecular mechanisms of resistance to the spread of radiation-induced lymphoma in a mouse mutant, survivor-27.

Y. Liu, A. Y. Savinov, D. L. McMinimy, S. G. Kremlev, Andrei Chapoval, I. K. Egorov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Metastatic tumors escape from immune response and spread in the body; survivors are very rare. Novel single exon genes A beta 4-7 and a pseudogene A beta 8 psi have been cloned from survivors. Their protein coding sequences are similar to MHC class II beta H2-Ab cDNA while their promoter is different from MHC promoters. The A beta 4 protein was demonstrated on macrophages (antigen presenting cells). The A beta gene family is genetically unstable in germ line and somatic cells of survivors. Mutants S-27 and S-87/1 lost the A beta 5s5 and acquired the A beta 6w302 gene; the Ab gene mutated in S-27. The proposed mechanism of resistance is molecular instability of the A beta gene family resulting in somatic mutations and wandering immune responses that destroy the tumor in the survivor.

Original languageEnglish (US)
Pages (from-to)500-505
Number of pages6
JournalRadiatsionnaia biologiia, radioecologiia / Rossiiskaia akademiia nauk
Volume40
Issue number5
StatePublished - Sep 1 2000
Externally publishedYes

Fingerprint

genes
mice
Lymphoma
Genes
Radiation
gene
radiation
immune response
tumor
Tumors
tumors
Tumor Escape
proteins
Proteins
Pseudogenes
macrophages
protein
Macrophages
antigens
Antigen-Presenting Cells

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Ecology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

The A beta 6w302 gene and molecular mechanisms of resistance to the spread of radiation-induced lymphoma in a mouse mutant, survivor-27. / Liu, Y.; Savinov, A. Y.; McMinimy, D. L.; Kremlev, S. G.; Chapoval, Andrei; Egorov, I. K.

In: Radiatsionnaia biologiia, radioecologiia / Rossiiskaia akademiia nauk, Vol. 40, No. 5, 01.09.2000, p. 500-505.

Research output: Contribution to journalArticle

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