The β-globin gene cluster distribution revisited - Patterns in native American populations

Sidia M. Callegari-Jacques, Shaiane G. Crossetti, Fabiana B. Kohlrausch, Francisco M. Salzano, Luiza T. Tsuneto, Maria Luiza Petzl-Erler, Kim Hill, Ana Hurtado, Mara H. Hutz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

New frequencies for the β-globin gene cluster haplotypes are presented for the Aché (N = 82 individuals), Guarani (N = 76), and Kaingang (N = 54), three Native South American populations that live in an area between parallels 20°S and 30°S not covered by previous studies at this locus. The haplotype frequencies obtained for the three populations are within the interval observed for 28 other Native American populations. The Aché show much less haplotypes (five) than the other two populations (9-10), the haplotype prevalences being more similar to those of the Guarani than to the Kaingang. The Native American total heterozygosity was about half (0.41) that obtained for the African populations (0.71), but was not much different from those obtained for other continents. A geographical pattern was disclosed in South America by mapping the frequencies of the most common haplotype (haplotype 2), and by means of spatial correlation analysis. The analysis of molecular variance (AMOVA) and pairwise FST data suggest three distinct sectors for the genetic landscape of Native South America: the Andes, the Center/Southeast region, and the Amazon.

Original languageEnglish (US)
Pages (from-to)190-197
Number of pages8
JournalAmerican Journal of Physical Anthropology
Volume134
Issue number2
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Globins
North American Indians
Multigene Family
multigene family
Haplotypes
haplotypes
Population
American Indians
South America
Spatial Analysis
analysis of variance
Analysis of Variance
heterozygosity
loci

Keywords

  • Genetic diversity
  • Language and genetics
  • South American gene geography

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anthropology

Cite this

Callegari-Jacques, S. M., Crossetti, S. G., Kohlrausch, F. B., Salzano, F. M., Tsuneto, L. T., Petzl-Erler, M. L., ... Hutz, M. H. (2007). The β-globin gene cluster distribution revisited - Patterns in native American populations. American Journal of Physical Anthropology, 134(2), 190-197. https://doi.org/10.1002/ajpa.20653

The β-globin gene cluster distribution revisited - Patterns in native American populations. / Callegari-Jacques, Sidia M.; Crossetti, Shaiane G.; Kohlrausch, Fabiana B.; Salzano, Francisco M.; Tsuneto, Luiza T.; Petzl-Erler, Maria Luiza; Hill, Kim; Hurtado, Ana; Hutz, Mara H.

In: American Journal of Physical Anthropology, Vol. 134, No. 2, 10.2007, p. 190-197.

Research output: Contribution to journalArticle

Callegari-Jacques, SM, Crossetti, SG, Kohlrausch, FB, Salzano, FM, Tsuneto, LT, Petzl-Erler, ML, Hill, K, Hurtado, A & Hutz, MH 2007, 'The β-globin gene cluster distribution revisited - Patterns in native American populations', American Journal of Physical Anthropology, vol. 134, no. 2, pp. 190-197. https://doi.org/10.1002/ajpa.20653
Callegari-Jacques SM, Crossetti SG, Kohlrausch FB, Salzano FM, Tsuneto LT, Petzl-Erler ML et al. The β-globin gene cluster distribution revisited - Patterns in native American populations. American Journal of Physical Anthropology. 2007 Oct;134(2):190-197. https://doi.org/10.1002/ajpa.20653
Callegari-Jacques, Sidia M. ; Crossetti, Shaiane G. ; Kohlrausch, Fabiana B. ; Salzano, Francisco M. ; Tsuneto, Luiza T. ; Petzl-Erler, Maria Luiza ; Hill, Kim ; Hurtado, Ana ; Hutz, Mara H. / The β-globin gene cluster distribution revisited - Patterns in native American populations. In: American Journal of Physical Anthropology. 2007 ; Vol. 134, No. 2. pp. 190-197.
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