TY - JOUR
T1 - The β-globin gene cluster distribution revisited - Patterns in native American populations
AU - Callegari-Jacques, Sidia M.
AU - Crossetti, Shaiane G.
AU - Kohlrausch, Fabiana B.
AU - Salzano, Francisco M.
AU - Tsuneto, Luiza T.
AU - Petzl-Erler, Maria Luiza
AU - Hill, Kim
AU - Hurtado, A. Magdalena
AU - Hutz, Mara H.
N1 - Funding Information:
ACKNOWLEDGMENT SAB gratfuelly acknowledges tathpart of this work was supportdeby EPSRC.
PY - 2007/10
Y1 - 2007/10
N2 - New frequencies for the β-globin gene cluster haplotypes are presented for the Aché (N = 82 individuals), Guarani (N = 76), and Kaingang (N = 54), three Native South American populations that live in an area between parallels 20°S and 30°S not covered by previous studies at this locus. The haplotype frequencies obtained for the three populations are within the interval observed for 28 other Native American populations. The Aché show much less haplotypes (five) than the other two populations (9-10), the haplotype prevalences being more similar to those of the Guarani than to the Kaingang. The Native American total heterozygosity was about half (0.41) that obtained for the African populations (0.71), but was not much different from those obtained for other continents. A geographical pattern was disclosed in South America by mapping the frequencies of the most common haplotype (haplotype 2), and by means of spatial correlation analysis. The analysis of molecular variance (AMOVA) and pairwise FST data suggest three distinct sectors for the genetic landscape of Native South America: the Andes, the Center/Southeast region, and the Amazon.
AB - New frequencies for the β-globin gene cluster haplotypes are presented for the Aché (N = 82 individuals), Guarani (N = 76), and Kaingang (N = 54), three Native South American populations that live in an area between parallels 20°S and 30°S not covered by previous studies at this locus. The haplotype frequencies obtained for the three populations are within the interval observed for 28 other Native American populations. The Aché show much less haplotypes (five) than the other two populations (9-10), the haplotype prevalences being more similar to those of the Guarani than to the Kaingang. The Native American total heterozygosity was about half (0.41) that obtained for the African populations (0.71), but was not much different from those obtained for other continents. A geographical pattern was disclosed in South America by mapping the frequencies of the most common haplotype (haplotype 2), and by means of spatial correlation analysis. The analysis of molecular variance (AMOVA) and pairwise FST data suggest three distinct sectors for the genetic landscape of Native South America: the Andes, the Center/Southeast region, and the Amazon.
KW - Genetic diversity
KW - Language and genetics
KW - South American gene geography
UR - http://www.scopus.com/inward/record.url?scp=34548766012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548766012&partnerID=8YFLogxK
U2 - 10.1002/ajpa.20653
DO - 10.1002/ajpa.20653
M3 - Article
C2 - 17596858
AN - SCOPUS:34548766012
SN - 0002-9483
VL - 134
SP - 190
EP - 197
JO - American journal of physical anthropology
JF - American journal of physical anthropology
IS - 2
ER -