Termination of Biological Function at Low Temperatures

Glass or Structural Transition?

Salman Seyedi, Dmitry Matyushov

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Energy of life is produced by electron transfer in energy chains of respiration or photosynthesis. A small input of free energy available to biology puts significant restrictions on how much free energy can be lost in each electron-transfer reaction. We advocate the view that breaking ergodicity, leading to violation of the fluctuation-dissipation theorem (FDT), is how proteins achieve high reaction rates without sacrificing the reaction free energy. Here we show that a significant level of nonergodicity, represented by a large extent of the configurational temperature over the kinetic temperature, is maintained in the entire physiological range for the cytochrome c electron transfer protein. The protein returns to the state consistent with the FDT below the crossover temperature close to the temperature of the protein glass transition. This crossover leads to a sharp increase in the activation barrier of electron transfer and is displayed by a kink in the Arrhenius plot for the reaction rate constant.

Original languageEnglish (US)
Pages (from-to)2359-2366
Number of pages8
JournalJournal of Physical Chemistry Letters
Volume9
Issue number9
DOIs
StatePublished - May 3 2018

Fingerprint

Electron transitions
electron transfer
Free energy
proteins
Proteins
Glass
Electrons
glass
free energy
Reaction rates
crossovers
reaction kinetics
dissipation
theorems
Arrhenius plots
Temperature
temperature
photosynthesis
Photosynthesis
cytochromes

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Termination of Biological Function at Low Temperatures : Glass or Structural Transition? / Seyedi, Salman; Matyushov, Dmitry.

In: Journal of Physical Chemistry Letters, Vol. 9, No. 9, 03.05.2018, p. 2359-2366.

Research output: Contribution to journalArticle

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