Temporal covariation of soluble interleukin‐2 receptor levels, daily stress, and disease activity in rheumatoid arthritis

Laura Harrington, Glenn Affleck, Susan Urrows, Howard Tennen, Pamela Higgins, Alex Zautra, Steven Hoffman

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Objective. To examine synchronous changes in soluble interleukin‐2 receptor (sIL‐2R) levels, daily indicators of emotional stress, joint inflammation, and reported pain in patients with rheumatoid arthritis (RA). Methods. Fourteen patients were studied on each of 6 occasions, 2 weeks apart. Measures included daily ratings of mood disturbance, undesirable events, and joint pain; clinical examination of joint swelling; and serum assays of sIL‐2R. Pooled within‐person correlations among these variables were calculated. Results. Consistent with the results of previous research, joint inflammation covaried directly with sIL‐2R levels. Changes in mood disturbance were unrelated to changes in joint inflammation, but increases in mood disturbance were linked with decreases in sIL‐2R levels and increases in reported joint pain. Conclusion. These findings provide preliminary evidence that psychoimmune processes may be implicated in short‐term changes in RA disease activity.

Original languageEnglish (US)
Pages (from-to)199-203
Number of pages5
JournalArthritis & Rheumatism
Volume36
Issue number2
DOIs
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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