Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery

Derek J. Overstreet, Ryan Y. McLemore, Brandon D. Doan, Amye Farag, Brent Vernon

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine® M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine® M-1000 caused a small LCST increase (0.24-0.27°C/wt%) and a broader sol-gel transition. Twenty wt% copolymer gels (Mw> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50%. Copolymer gels eluted <20% of ovalbumin over 6 days whereas homopolymer gels released >90% within 3 h. These results suggest that Jeffamine® M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.

Original languageEnglish (US)
Pages (from-to)294-304
Number of pages11
JournalSoft Materials
Volume11
Issue number3
DOIs
StatePublished - Jul 1 2013

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Keywords

  • Drug delivery
  • Graft copolymer
  • N -isopropylacrylamide
  • Swelling
  • Temperature-responsive polymer

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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