Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery

Derek J. Overstreet, Ryan Y. McLemore, Brandon D. Doan, Amye Farag, Brent Vernon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine® M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine® M-1000 caused a small LCST increase (0.24-0.27°C/wt%) and a broader sol-gel transition. Twenty wt% copolymer gels (Mw> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50%. Copolymer gels eluted <20% of ovalbumin over 6 days whereas homopolymer gels released >90% within 3 h. These results suggest that Jeffamine® M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.

Original languageEnglish (US)
Pages (from-to)294-304
Number of pages11
JournalSoft Materials
Volume11
Issue number3
DOIs
StatePublished - Jul 1 2013

Fingerprint

Hydrogels
Graft copolymers
Drug delivery
swelling
Swelling
delivery
copolymers
drugs
Gels
Acrylamide
gels
Copolymers
Biocompatible Materials
Homopolymerization
body temperature
Biomaterials
Temperature
Sol-gels
temperature
inclusions

Keywords

  • Drug delivery
  • Graft copolymer
  • N -isopropylacrylamide
  • Swelling
  • Temperature-responsive polymer

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Chemistry(all)

Cite this

Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery. / Overstreet, Derek J.; McLemore, Ryan Y.; Doan, Brandon D.; Farag, Amye; Vernon, Brent.

In: Soft Materials, Vol. 11, No. 3, 01.07.2013, p. 294-304.

Research output: Contribution to journalArticle

Overstreet, Derek J. ; McLemore, Ryan Y. ; Doan, Brandon D. ; Farag, Amye ; Vernon, Brent. / Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery. In: Soft Materials. 2013 ; Vol. 11, No. 3. pp. 294-304.
@article{361c0b2e83ed4030bbaa07edf137e674,
title = "Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery",
abstract = "Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine{\circledR} M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine{\circledR} M-1000 caused a small LCST increase (0.24-0.27°C/wt{\%}) and a broader sol-gel transition. Twenty wt{\%} copolymer gels (Mw> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50{\%}. Copolymer gels eluted <20{\%} of ovalbumin over 6 days whereas homopolymer gels released >90{\%} within 3 h. These results suggest that Jeffamine{\circledR} M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.",
keywords = "Drug delivery, Graft copolymer, N -isopropylacrylamide, Swelling, Temperature-responsive polymer",
author = "Overstreet, {Derek J.} and McLemore, {Ryan Y.} and Doan, {Brandon D.} and Amye Farag and Brent Vernon",
year = "2013",
month = "7",
day = "1",
doi = "10.1080/1539445X.2011.640731",
language = "English (US)",
volume = "11",
pages = "294--304",
journal = "Soft Materials",
issn = "1539-445X",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Temperature-responsive graft copolymer hydrogels for controlled swelling and drug delivery

AU - Overstreet, Derek J.

AU - McLemore, Ryan Y.

AU - Doan, Brandon D.

AU - Farag, Amye

AU - Vernon, Brent

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine® M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine® M-1000 caused a small LCST increase (0.24-0.27°C/wt%) and a broader sol-gel transition. Twenty wt% copolymer gels (Mw> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50%. Copolymer gels eluted <20% of ovalbumin over 6 days whereas homopolymer gels released >90% within 3 h. These results suggest that Jeffamine® M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.

AB - Temperature-responsive graft copolymers of N-isopropylacrylamide and Jeffamine® M-1000 acrylamide were synthesized to provide controlled swelling without introducing degradable moieties or increasing the LCST above body temperature. Jeffamine® M-1000 caused a small LCST increase (0.24-0.27°C/wt%) and a broader sol-gel transition. Twenty wt% copolymer gels (Mw> 225 kDa) retained their initial volume after 42 days, while homopolymer gels shrank by more than 50%. Copolymer gels eluted <20% of ovalbumin over 6 days whereas homopolymer gels released >90% within 3 h. These results suggest that Jeffamine® M-1000 acrylamide is suitable for inclusion in N-isopropylacrylamide-based biomaterials to control swelling and drug release nearly independently of LCST.

KW - Drug delivery

KW - Graft copolymer

KW - N -isopropylacrylamide

KW - Swelling

KW - Temperature-responsive polymer

UR - http://www.scopus.com/inward/record.url?scp=84874409080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874409080&partnerID=8YFLogxK

U2 - 10.1080/1539445X.2011.640731

DO - 10.1080/1539445X.2011.640731

M3 - Article

AN - SCOPUS:84874409080

VL - 11

SP - 294

EP - 304

JO - Soft Materials

JF - Soft Materials

SN - 1539-445X

IS - 3

ER -