TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development

Alain P. Vicari; David J. Figueroa; Joseph A. Hedrick; Jessica S. Foster; Komal P. Singh; Satish Menon; N. G. Copeland; D. J. Gilbert; N. A. Jenkins; Kevin B. Bacon; Albert Zlotnik

doi:10.1016/S1074-7613(00)80531-2

TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development

Alain P. Vicari, David J. Figueroa, Joseph A. Hedrick, Jessica S. Foster, Komal P. Singh, Satish Menon, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, Kevin B. Bacon, Albert Zlotnik

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252 Scopus citations

Abstract

A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was detected at substantial levels in the small intestine and at low levels in the liver. The source of TECK in the thymus was determined to be thymic dendritic cells; in contrast, bone marrow-derived dendritic cells do not express TECK. The murine TECK recombinant protein showed chemotactic activity for activated macrophages, dendritic cells, and thymocytes. We conclude that TECK represents a novel thymic dendritic cell- specific CC chemokine that is possibly involved in T cell development.

Original language	English (US)
Pages (from-to)	291-301
Number of pages	11
Journal	Immunity
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/S1074-7613(00)80531-2
State	Published - Aug 1997
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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@article{9cb4c67d83444366a9b5ca612dd25ace,

title = "TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development",

abstract = "A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was detected at substantial levels in the small intestine and at low levels in the liver. The source of TECK in the thymus was determined to be thymic dendritic cells; in contrast, bone marrow-derived dendritic cells do not express TECK. The murine TECK recombinant protein showed chemotactic activity for activated macrophages, dendritic cells, and thymocytes. We conclude that TECK represents a novel thymic dendritic cell- specific CC chemokine that is possibly involved in T cell development.",

author = "Vicari, {Alain P.} and Figueroa, {David J.} and Hedrick, {Joseph A.} and Foster, {Jessica S.} and Singh, {Komal P.} and Satish Menon and Copeland, {N. G.} and Gilbert, {D. J.} and Jenkins, {N. A.} and Bacon, {Kevin B.} and Albert Zlotnik",

note = "Funding Information: Correspondence should be addressed to A. Z. (e-mail: zlotnik@ dnax.org). We are grateful to T. MacClanahan, K. Franz-Bacon, and M. F. Sterling for the construction and availability of most of the cDNA libraries used in this report. We also thank J. Cupp, E. Callas, J. Poliakoff, and E. Murphy for cell sorting and A. Helms and C. Huffine for DNA sequencing. DNAX Research Institute is supported by Schering-Plough, Inc.",

year = "1997",

month = aug,

doi = "10.1016/S1074-7613(00)80531-2",

language = "English (US)",

volume = "7",

pages = "291--301",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - TECK

T2 - A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development

AU - Vicari, Alain P.

AU - Figueroa, David J.

AU - Hedrick, Joseph A.

AU - Foster, Jessica S.

AU - Singh, Komal P.

AU - Menon, Satish

AU - Copeland, N. G.

AU - Gilbert, D. J.

AU - Jenkins, N. A.

AU - Bacon, Kevin B.

AU - Zlotnik, Albert

N1 - Funding Information: Correspondence should be addressed to A. Z. (e-mail: zlotnik@ dnax.org). We are grateful to T. MacClanahan, K. Franz-Bacon, and M. F. Sterling for the construction and availability of most of the cDNA libraries used in this report. We also thank J. Cupp, E. Callas, J. Poliakoff, and E. Murphy for cell sorting and A. Helms and C. Huffine for DNA sequencing. DNAX Research Institute is supported by Schering-Plough, Inc.

PY - 1997/8

Y1 - 1997/8

N2 - A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was detected at substantial levels in the small intestine and at low levels in the liver. The source of TECK in the thymus was determined to be thymic dendritic cells; in contrast, bone marrow-derived dendritic cells do not express TECK. The murine TECK recombinant protein showed chemotactic activity for activated macrophages, dendritic cells, and thymocytes. We conclude that TECK represents a novel thymic dendritic cell- specific CC chemokine that is possibly involved in T cell development.

AB - A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was detected at substantial levels in the small intestine and at low levels in the liver. The source of TECK in the thymus was determined to be thymic dendritic cells; in contrast, bone marrow-derived dendritic cells do not express TECK. The murine TECK recombinant protein showed chemotactic activity for activated macrophages, dendritic cells, and thymocytes. We conclude that TECK represents a novel thymic dendritic cell- specific CC chemokine that is possibly involved in T cell development.

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TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development

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