TY - JOUR
T1 - Targetry and radiochemical methods for the simultaneous cyclotron production of no-carrier-added radiopharmaceutical-quality 100Pd, 97Ru and 101mRh
AU - Lagunas-Solar, Manuel C.
AU - Avila, Mario J.
AU - Johnson, Paul C.
N1 - Funding Information:
Acknowledgements-The authors wish to thank Mr Joel McCurdy, Chief of Operations, and to Mr Walter Kemmler, of the Mechanical Shop at Cracker Nuclear Laboratory, for their help and assistance during the irradiations and target fabrication. Our thanks also to Mr Neal J. Navarro for his assistance during the early stages of this study, and to the Radioisotope Program personnel. This work was funded by the Radioisotope Program and the Cracker Nuclear Laboratory’s Research Grants and in part by the Department of Energy Contract No. 25046, Cancer Radioimmunotherapy.
PY - 1987
Y1 - 1987
N2 - Target-dissolution and radiochemical methods were investigated to optimize the simultaneous production of radio-pharmaceutical-quality, no-carrier-added (NCA) 3.63-d 100Pd, 2.88-d 97Ru and 4.26-d 101mRh. These radionuclides have potential as radiotracer labels and/or as short-range dose emitters for use with specific-function radiopharmaceuticals being investigated for radioimmunotherapy applications. Metallic Rh (100% 103Rh) and RhCl3 × 3H2O were used as target materials. After bombardment with high energy protons these targets were subjected to a combination of procedures (i.e. electrolytic dissolution, ion-exchange, and solvent extraction) in order to separate the desired radionuclides. The use of a single cyclotron target in combination with several radiochemical processes were investigated to simultaneously produce these radionuclides in high-specific activities and radiochemical forms suitable for radiopharmaceutical syntheses.
AB - Target-dissolution and radiochemical methods were investigated to optimize the simultaneous production of radio-pharmaceutical-quality, no-carrier-added (NCA) 3.63-d 100Pd, 2.88-d 97Ru and 4.26-d 101mRh. These radionuclides have potential as radiotracer labels and/or as short-range dose emitters for use with specific-function radiopharmaceuticals being investigated for radioimmunotherapy applications. Metallic Rh (100% 103Rh) and RhCl3 × 3H2O were used as target materials. After bombardment with high energy protons these targets were subjected to a combination of procedures (i.e. electrolytic dissolution, ion-exchange, and solvent extraction) in order to separate the desired radionuclides. The use of a single cyclotron target in combination with several radiochemical processes were investigated to simultaneously produce these radionuclides in high-specific activities and radiochemical forms suitable for radiopharmaceutical syntheses.
UR - http://www.scopus.com/inward/record.url?scp=0023139187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023139187&partnerID=8YFLogxK
U2 - 10.1016/0883-2889(87)90013-X
DO - 10.1016/0883-2889(87)90013-X
M3 - Article
C2 - 3032863
AN - SCOPUS:0023139187
SN - 0883-2889
VL - 38
SP - 151
EP - 157
JO - International Journal of Radiation Applications and Instrumentation. Part
JF - International Journal of Radiation Applications and Instrumentation. Part
IS - 2
ER -