Targetry and radiochemical methods for the simultaneous cyclotron production of no-carrier-added radiopharmaceutical-quality 100Pd, 97Ru and 101mRh

Manuel C. Lagunas-Solar, Mario J. Avila, Paul C. Johnson

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Abstract

Target-dissolution and radiochemical methods were investigated to optimize the simultaneous production of radio-pharmaceutical-quality, no-carrier-added (NCA) 3.63-d 100Pd, 2.88-d 97Ru and 4.26-d 101mRh. These radionuclides have potential as radiotracer labels and/or as short-range dose emitters for use with specific-function radiopharmaceuticals being investigated for radioimmunotherapy applications. Metallic Rh (100% 103Rh) and RhCl3 × 3H2O were used as target materials. After bombardment with high energy protons these targets were subjected to a combination of procedures (i.e. electrolytic dissolution, ion-exchange, and solvent extraction) in order to separate the desired radionuclides. The use of a single cyclotron target in combination with several radiochemical processes were investigated to simultaneously produce these radionuclides in high-specific activities and radiochemical forms suitable for radiopharmaceutical syntheses.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume38
Issue number2
DOIs
StatePublished - 1987

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ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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