Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites

M. Manuela Rigano, Francesco Sala, Charles J. Arntzen, Amanda M. Walmsley

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Most pathogenic microorganisms enter their host via the mucosal surfaces lining the digestive, respiratory and urino-reproductive tracts of the body. The most efficient means of protecting these surfaces is through mucosal immunization. Transgenic plants are safe and inexpensive vehicles to produce and mucosally deliver protective antigens. However, the application of this technology is limited by the poor response of the immune system to non-particulate, subunit vaccines. Co-delivery of therapeutic proteins with targeting proteins, such as the B subunit of the Escherichia coli heat labile enterotoxin (LTB), could increase the effectiveness of such antigens.

Original languageEnglish (US)
Pages (from-to)809-811
Number of pages3
JournalVaccine
Volume21
Issue number7-8
DOIs
StatePublished - Jan 30 2003

Keywords

  • Mucosal immune system
  • Transgenic plants
  • Vaccines

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Rigano, M. M., Sala, F., Arntzen, C. J., & Walmsley, A. M. (2003). Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites. Vaccine, 21(7-8), 809-811. https://doi.org/10.1016/S0264-410X(02)00604-7