Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites

M. Manuela Rigano; Francesco Sala; Charles J. Arntzen; Amanda M. Walmsley

doi:10.1016/S0264-410X(02)00604-7

Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites

M. Manuela Rigano, Francesco Sala, Charles J. Arntzen, Amanda M. Walmsley

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Most pathogenic microorganisms enter their host via the mucosal surfaces lining the digestive, respiratory and urino-reproductive tracts of the body. The most efficient means of protecting these surfaces is through mucosal immunization. Transgenic plants are safe and inexpensive vehicles to produce and mucosally deliver protective antigens. However, the application of this technology is limited by the poor response of the immune system to non-particulate, subunit vaccines. Co-delivery of therapeutic proteins with targeting proteins, such as the B subunit of the Escherichia coli heat labile enterotoxin (LTB), could increase the effectiveness of such antigens.

Original language	English (US)
Pages (from-to)	809-811
Number of pages	3
Journal	Vaccine
Volume	21
Issue number	7-8
DOIs	https://doi.org/10.1016/S0264-410X(02)00604-7
State	Published - Jan 30 2003

Keywords

Mucosal immune system
Transgenic plants
Vaccines

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(02)00604-7

Cite this

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title = "Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites",

abstract = "Most pathogenic microorganisms enter their host via the mucosal surfaces lining the digestive, respiratory and urino-reproductive tracts of the body. The most efficient means of protecting these surfaces is through mucosal immunization. Transgenic plants are safe and inexpensive vehicles to produce and mucosally deliver protective antigens. However, the application of this technology is limited by the poor response of the immune system to non-particulate, subunit vaccines. Co-delivery of therapeutic proteins with targeting proteins, such as the B subunit of the Escherichia coli heat labile enterotoxin (LTB), could increase the effectiveness of such antigens.",

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note = "Funding Information: The authors would like to thank Lucrecia Alvarez, Julia Pinkhasov, Yuguang Jin and Dwayne Kirk for their contributions. This work is partially supported by Dow AgroSciences LLC.",

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AU - Rigano, M. Manuela

AU - Sala, Francesco

AU - Arntzen, Charles J.

AU - Walmsley, Amanda M.

N1 - Funding Information: The authors would like to thank Lucrecia Alvarez, Julia Pinkhasov, Yuguang Jin and Dwayne Kirk for their contributions. This work is partially supported by Dow AgroSciences LLC.

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Y1 - 2003/1/30

N2 - Most pathogenic microorganisms enter their host via the mucosal surfaces lining the digestive, respiratory and urino-reproductive tracts of the body. The most efficient means of protecting these surfaces is through mucosal immunization. Transgenic plants are safe and inexpensive vehicles to produce and mucosally deliver protective antigens. However, the application of this technology is limited by the poor response of the immune system to non-particulate, subunit vaccines. Co-delivery of therapeutic proteins with targeting proteins, such as the B subunit of the Escherichia coli heat labile enterotoxin (LTB), could increase the effectiveness of such antigens.

AB - Most pathogenic microorganisms enter their host via the mucosal surfaces lining the digestive, respiratory and urino-reproductive tracts of the body. The most efficient means of protecting these surfaces is through mucosal immunization. Transgenic plants are safe and inexpensive vehicles to produce and mucosally deliver protective antigens. However, the application of this technology is limited by the poor response of the immune system to non-particulate, subunit vaccines. Co-delivery of therapeutic proteins with targeting proteins, such as the B subunit of the Escherichia coli heat labile enterotoxin (LTB), could increase the effectiveness of such antigens.

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Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites

Abstract

Keywords

ASJC Scopus subject areas

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