Targeted motor rehabilitation dissociates corticobulbar versus corticospinal dysfunction in an animal model of parkinson's disease

Emily K. Plowman, Nicholas Maling, Nagheme J. Thomas, Stephen C. Fowler, Jeffrey Kleim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background. Recent evidence suggests that motor training may be beneficial for slowing the onset of motor impairments in Parkinson's disease (PD). Objective. To examine the impact of targeted rehabilitation on limb motor and cranial motor function and the corresponding corticospinal and corticobulbar circuits in a rodent model of PD. Methods. Baseline performance of limb (reaching) and cranial (licking) motor function were established prior to and 6 weeks following unilateral intrastriatal 6-hydroxydopamine (6-OHDA) infusions. Animals then received 6 weeks of limb motor rehabilitation (LMR) or cranial motor rehabilitation (CMR), after which motor performance was reassessed. Intracortical microstimulation (ICMS) was used to generate motor maps of corresponding corticospinal (forelimb) and corticobulbar (tongue) movement representations within the motor cortex ipsilateral to the 6-OHDA infusion. Quantitative tyrosine hydroxylase (TH) immunohistochemistry was performed to determine levels of striatal TH depletion in 6-OHDA animals using near infrared densitometry. Results. (1) unilateral intrastriatal dopamine depletion impaired both reaching accuracy and lick force; (2) targeted LMR ameliorated impairments in reaching performance; however, CMR did not improve lick force impairments; (3) unilateral dopamine depletion significantly reduced forelimb but not tongue motor map topography; (4) LMR partially restored forelimb motor maps, whereas CMR did not alter tongue motor maps; and (5) significant correlations were observed between skilled reaching accuracy, forelimb motor map area, and TH depletion, but no relationships were revealed for cranial motor function, motor maps, or TH depletion. Conclusions: These data demonstrate dissociation between striatal dopamine depletion, limb versus cranial motor function, and targeted motor rehabilitation in a rodent model of PD.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalNeurorehabilitation and Neural Repair
Volume28
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Parkinson Disease
Rehabilitation
Animal Models
Extremities
Forelimb
Oxidopamine
Tyrosine 3-Monooxygenase
Tongue
Corpus Striatum
Dopamine
Motor Cortex
Rodentia
Densitometry
Immunohistochemistry

Keywords

  • 6-hydroxydopamine
  • corticobulbar
  • corticospinal
  • cranial
  • intracortical microstimulation
  • limb
  • motor maps
  • Parkinson's disease
  • rehabilitation
  • rodent

ASJC Scopus subject areas

  • Clinical Neurology
  • Rehabilitation
  • Neurology

Cite this

Targeted motor rehabilitation dissociates corticobulbar versus corticospinal dysfunction in an animal model of parkinson's disease. / Plowman, Emily K.; Maling, Nicholas; Thomas, Nagheme J.; Fowler, Stephen C.; Kleim, Jeffrey.

In: Neurorehabilitation and Neural Repair, Vol. 28, No. 1, 01.2014, p. 85-95.

Research output: Contribution to journalArticle

Plowman, Emily K. ; Maling, Nicholas ; Thomas, Nagheme J. ; Fowler, Stephen C. ; Kleim, Jeffrey. / Targeted motor rehabilitation dissociates corticobulbar versus corticospinal dysfunction in an animal model of parkinson's disease. In: Neurorehabilitation and Neural Repair. 2014 ; Vol. 28, No. 1. pp. 85-95.
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AB - Background. Recent evidence suggests that motor training may be beneficial for slowing the onset of motor impairments in Parkinson's disease (PD). Objective. To examine the impact of targeted rehabilitation on limb motor and cranial motor function and the corresponding corticospinal and corticobulbar circuits in a rodent model of PD. Methods. Baseline performance of limb (reaching) and cranial (licking) motor function were established prior to and 6 weeks following unilateral intrastriatal 6-hydroxydopamine (6-OHDA) infusions. Animals then received 6 weeks of limb motor rehabilitation (LMR) or cranial motor rehabilitation (CMR), after which motor performance was reassessed. Intracortical microstimulation (ICMS) was used to generate motor maps of corresponding corticospinal (forelimb) and corticobulbar (tongue) movement representations within the motor cortex ipsilateral to the 6-OHDA infusion. Quantitative tyrosine hydroxylase (TH) immunohistochemistry was performed to determine levels of striatal TH depletion in 6-OHDA animals using near infrared densitometry. Results. (1) unilateral intrastriatal dopamine depletion impaired both reaching accuracy and lick force; (2) targeted LMR ameliorated impairments in reaching performance; however, CMR did not improve lick force impairments; (3) unilateral dopamine depletion significantly reduced forelimb but not tongue motor map topography; (4) LMR partially restored forelimb motor maps, whereas CMR did not alter tongue motor maps; and (5) significant correlations were observed between skilled reaching accuracy, forelimb motor map area, and TH depletion, but no relationships were revealed for cranial motor function, motor maps, or TH depletion. Conclusions: These data demonstrate dissociation between striatal dopamine depletion, limb versus cranial motor function, and targeted motor rehabilitation in a rodent model of PD.

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