Taking advantage of tailored electrostatics and complementary hydrogen bonding in the design of nanostructures for biomedical applications

Matthew T. Hunley, Afia S. Karikari, Matthew G. McKee, Brian D. Mather, John M. Layman, Ann R. Fornof, Timothy E. Long

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Four-armed, star-shaped poly(D,L-lactide) (PDLLA) was synthesized and terminally-functionalized with either adenine or thymine complementary hydrogen bonding groups (PDLLA-A and PDLLA-T, respectively). The strong hydrogen bonding led to increased viscosity below the dissociation temperature of the hydrogen bonds. Rheology confirmed that these bonds were thermally reversible, with a sharp reduction in viscosity near 100°C. PDLLA, PDLLA-A, and PDLLA-T were melt electrospun with no significant change in fiber diameter (all between 3.6 and 4.0 μm). However, a blend of PDLLA-A and PDLLA-T formed fibers with an average diameter of 9.8 ± 2.0 μm, resulting from the hydrogen bond associations. Also, the phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine (POPE) was melt electrospun at 200°C and formed uniform fibers with average fiber diameter of 6.5 ± 2.0 μm.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalMacromolecular Symposia
Volume270
Issue number1
DOIs
StatePublished - Aug 2008
Externally publishedYes

Keywords

  • Hydrogen bonding
  • Melt electrospinning
  • Phospholipids
  • Poly(D,L-lactide)
  • Thermoreversible

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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