TY - JOUR
T1 - T-lymphocyte reactivity during the menstrual cycle in women
AU - Caggiula, Anthony R.
AU - Stoney, Catherine M.
AU - Matthews, Karen A.
AU - Owens, Jane F.
AU - Davis, Mary C.
AU - Rabin, Bruce S.
N1 - Funding Information:
We gratefully acknowledge the expert assistance of Leslie Gedman and Richard Nelson. This work was supported by Grants HL-38712 and MH-4341.
PY - 1990/7
Y1 - 1990/7
N2 - Reactivity of blood lymphocytes to nonspecific mitogenic stimulation with phytohemagglutinin (PHA) was measured in nine healthy, regularly cycling women at three phases of their menstrual cycles corresponding to peak levels of estradiol (midfollicular phase), peak levels of progresterone (midluteal phase), and the lowest levels of both hormones (menstrual phase). Sampling points were verified by radioimmunoassay of estrogen, progesterone, luteinizing hormone, and follicle-stimulating hormone. There were significant increases in reactivity associated with an increasing concentration of PHA and with autologous plasma vs AB plasma. However, no differences were found in reactivity to PHA over the three menstrual cycle phases and correlational analyses indicated no relationship between counts and any of the hormones measured.
AB - Reactivity of blood lymphocytes to nonspecific mitogenic stimulation with phytohemagglutinin (PHA) was measured in nine healthy, regularly cycling women at three phases of their menstrual cycles corresponding to peak levels of estradiol (midfollicular phase), peak levels of progresterone (midluteal phase), and the lowest levels of both hormones (menstrual phase). Sampling points were verified by radioimmunoassay of estrogen, progesterone, luteinizing hormone, and follicle-stimulating hormone. There were significant increases in reactivity associated with an increasing concentration of PHA and with autologous plasma vs AB plasma. However, no differences were found in reactivity to PHA over the three menstrual cycle phases and correlational analyses indicated no relationship between counts and any of the hormones measured.
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U2 - 10.1016/0090-1229(90)90177-R
DO - 10.1016/0090-1229(90)90177-R
M3 - Article
C2 - 2113445
AN - SCOPUS:0025316329
SN - 0090-1229
VL - 56
SP - 130
EP - 134
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 1
ER -