T-cell and chemokine receptor variation in South Amerindian populations

Tabita Hünemeier, Andrei G. Neves, Igor Nornberg, Kim Hill, A. Magdalena Hurtado, Francisco R. Carnese, Alicia S. Goicoechea, Mara H. Hutz, Francisco M. Salzano, José A.B. Chies

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The immune response of relatively small, endogamous populations is of special interest, because they may differ from those of large, ethnically diverse, urban groups. As a contribution to this area of investigation, we tested 99 individuals from two Brazilian native populations for two T-cell receptor gene segments (TCRBV3S1 and TCRBV18) and 241 subjects from eight tribes of this ethnic group in relation to the chemokine receptor CCR5Δ32 allele. Differences in TCRBV3S1 and TCRBV18 prevalences of the Amerindians in relation to European- and African-derived individuals were not marked. We confirmed the absence of the CCR5Δ32 allele in most groups, its presence in the Mura and Kaingang, probably because of European gene introgression.

Original languageEnglish (US)
Pages (from-to)515-518
Number of pages4
JournalAmerican Journal of Human Biology
Volume17
Issue number4
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Ecology, Evolution, Behavior and Systematics
  • Anthropology
  • Genetics

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