Synthetic vaccines: Immunity without harm

Abhinav P. Acharya, Niren Murthy

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A study was conducted to demonstrate that multilamellar lipid vesicles with crosslinked walls carrying protein antigens in the vesicle core and immunostimulatory drugs in the vesicle walls generated immune responses comparable to the strongest live vector vaccines. Investigations revealed that multilamellar lipid vesicles also entrapped immunostimulatory Toll-like receptor (TLR) ligands in between bilayers. The researchers engaged in the study showed that the crosslinked liposomes acted as a controlled-release reservoir of protein antigen and targeted dendritic cells in vivo. Dendritic-cell targeting was found to be a key part of the multi-step process by which vaccines activate antigen-specific memory T cells recognized and rapidly cleared pathogens that caused previous infections.

Original languageEnglish (US)
Pages (from-to)166-168
Number of pages3
JournalNature materials
Volume10
Issue number3
DOIs
StatePublished - Mar 2011
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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