Synthetic hydrogenases: Incorporation of an iron carbonyl thiolate into a designed peptide

Anne Jones, Bruce R. Lichtenstein, Arnab Dutta, Gwyneth Gordon, P. Leslie Dutton

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Abstract

[FeFe] hydrogenases catalyze reversible hydrogen oxidation at an unusual organometallic active site. Neither enzymatic studies nor synthesis of small molecule models has managed to elucidate the mechanisms of these enzymes. In this paper, we demonstrate the incorporation of an iron carbonyl thiolate mimic of the hydrogenase active site into a de novo artificial peptide, creating the first peptide-based model system for hydrogenases.

Original languageEnglish (US)
Pages (from-to)14844-14845
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number48
DOIs
StatePublished - Dec 5 2007

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ASJC Scopus subject areas

  • Chemistry(all)

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