Synthetic hydrogenases: Incorporation of an iron carbonyl thiolate into a designed peptide

Anne Jones, Bruce R. Lichtenstein, Arnab Dutta, Gwyneth Gordon, P. Leslie Dutton

Research output: Contribution to journalArticle

72 Scopus citations


[FeFe] hydrogenases catalyze reversible hydrogen oxidation at an unusual organometallic active site. Neither enzymatic studies nor synthesis of small molecule models has managed to elucidate the mechanisms of these enzymes. In this paper, we demonstrate the incorporation of an iron carbonyl thiolate mimic of the hydrogenase active site into a de novo artificial peptide, creating the first peptide-based model system for hydrogenases.

Original languageEnglish (US)
Pages (from-to)14844-14845
Number of pages2
JournalJournal of the American Chemical Society
Issue number48
StatePublished - Dec 5 2007


ASJC Scopus subject areas

  • Chemistry(all)

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