Abstract
Thermally reversible polymer gels with lower critical solution temperatures (LCST) below physiological temperature were studied for the development of a refillable biohybrid artificial pancreas. Differential scanning calorimetry indicated an increase in LCST with the addition of acrylic acid. The polymer Poly(N-isopropylacrylamide) [P(NIPAAm)] exhibited a peak at 32 °C and Poly(N-isopropylacrylamide-co-Acrylic acid) showed a peak at 35 °C. P(NIPAAm) exhibited extreme syneresis, forming a tight, dense, gel matrix. Decrease in syneresis and volume reduction in the acrylic acid copolymer improved the efficiency of islet immobilization.
| Original language | English (US) |
|---|---|
| Title of host publication | Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium |
| Editors | Anon |
| Place of Publication | St. Louis Park, MN, United States |
| Publisher | Soc for Biomaterials |
| Pages | 870 |
| Number of pages | 1 |
| Volume | 1 |
| State | Published - 1996 |
| Externally published | Yes |
| Event | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996 |
Other
| Other | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) |
|---|---|
| City | Toronto, Can |
| Period | 5/29/96 → 6/2/96 |
ASJC Scopus subject areas
- General Materials Science