Synthetic extracellular matrix for islets of Langerhans in development of biohybrid artificial pancreas using thermally reversible polymer gels

Brent Vernon, S. W. Kim, Y. H. Bae

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Thermally reversible polymer gels with lower critical solution temperatures (LCST) below physiological temperature were studied for the development of a refillable biohybrid artificial pancreas. Differential scanning calorimetry indicated an increase in LCST with the addition of acrylic acid. The polymer Poly(N-isopropylacrylamide) [P(NIPAAm)] exhibited a peak at 32 °C and Poly(N-isopropylacrylamide-co-Acrylic acid) showed a peak at 35 °C. P(NIPAAm) exhibited extreme syneresis, forming a tight, dense, gel matrix. Decrease in syneresis and volume reduction in the acrylic acid copolymer improved the efficiency of islet immobilization.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
Place of PublicationSt. Louis Park, MN, United States
PublisherSoc for Biomaterials
Pages870
Number of pages1
Volume1
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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    Vernon, B., Kim, S. W., & Bae, Y. H. (1996). Synthetic extracellular matrix for islets of Langerhans in development of biohybrid artificial pancreas using thermally reversible polymer gels. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1, pp. 870). Soc for Biomaterials.