Synthetic developmental biology

build and control multicellular systems

Mohammad Ebrahimkhani, Miki Ebisuya

Research output: Contribution to journalReview article

Abstract

Synthetic biology offers a bottom–up engineering approach that intends to understand complex systems via design-build-test cycles. Embryonic development comprises complex processes that originate at the level of gene regulatory networks in a cell and emerge into collective cellular behaviors with multicellular forms and functions. Here, we review synthetic biology approaches to development that involve building de novo developmental trajectories or engineering control in stem cell-derived multicellular systems. The field of synthetic developmental biology is rapidly growing with the help of recent advances in artificial gene circuits, self-organizing organoids, and controllable tissue microenvironments. The outcome will be a blueprint to decode principles of morphogenesis and to create programmable organoids with novel designs or improved functions.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume52
DOIs
StatePublished - Oct 1 2019

Fingerprint

Synthetic Biology
Developmental Biology
Organoids
Genes
Gene Regulatory Networks
Control systems
Blueprints
Stem cells
Synthetic Genes
Large scale systems
Trajectories
Tissue
Morphogenesis
Embryonic Development
Networks (circuits)
Stem Cells

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Synthetic developmental biology : build and control multicellular systems. / Ebrahimkhani, Mohammad; Ebisuya, Miki.

In: Current Opinion in Chemical Biology, Vol. 52, 01.10.2019, p. 9-15.

Research output: Contribution to journalReview article

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