Synthetic Antibacterial Peptide Exhibits Synergy with Oxacillin against MRSA

John C. Lainson, Seth M. Daly, Kathleen Triplett, Stephen Johnston, Pamela R. Hall, Chris Diehnelt

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

One proposed solution to the crisis of antimicrobial resistant (AMR) infections is the development of molecules that potentiate the activity of antibiotics for AMR bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Rather than develop broad spectrum compounds, we developed a peptide that could potentiate the activity of a narrow spectrum antibiotic, oxacillin. In this way, the combination treatment could narrowly target the resistant pathogen and limit impact on host flora. We developed a peptide, ASU014, composed of a S. aureus binding peptide and a S. aureus inhibitory peptide conjugated to a branched peptide scaffold, which has modest activity against S. aureus but exhibits synergy with oxacillin for MRSA both in vitro and in a MRSA skin infection model. The low concentration of ASU014 and sub-MIC concentration of oxacillin necessary for activity suggest that this molecule is a candidate for future medicinal chemistry optimization.

Original languageEnglish (US)
Pages (from-to)853-857
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume8
Issue number8
DOIs
StatePublished - Aug 10 2017

Keywords

  • antibacterial peptide
  • MRSA
  • oxacillin
  • potentiator

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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