The 81-85 segment of tobacco mosaic virus protein has been prepared by two different synthetic approaches. Synthesis of the protected pentapeptide N-benzyloxycarbonyl-L-threonyl-L-alanyl-L-leucyl-L-leucyl-glycine hydrazide corresponding to TMV protein 81-85 was accomplished employing as key step coupling of N-Z-Thr-Ala azide with Leu-Leu-Gly-OMe. The product was identical with the same pentapeptide obtained by a Merrifield solid-phase synthesis.
ASJC Scopus subject areas
- Organic Chemistry