Synthesis of Tobacco Mosaic Virus Protein Sequence 81-851

George Pettit, William R. Jones

Research output: Contribution to journalArticle

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Abstract

The 81-85 segment of tobacco mosaic virus protein has been prepared by two different synthetic approaches. Synthesis of the protected pentapeptide N-benzyloxycarbonyl-L-threonyl-L-alanyl-L-leucyl-L-leucyl-glycine hydrazide corresponding to TMV protein 81-85 was accomplished employing as key step coupling of N-Z-Thr-Ala azide with Leu-Leu-Gly-OMe. The product was identical with the same pentapeptide obtained by a Merrifield solid-phase synthesis.

Original languageEnglish (US)
Pages (from-to)870-873
Number of pages4
JournalJournal of Organic Chemistry
Volume36
Issue number7
DOIs
StatePublished - Apr 1 1971

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ASJC Scopus subject areas

  • Organic Chemistry

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