Synthesis of the carbohydrate moiety of bleomycin

Vince Pozsgay, Tadaaki Ohgi, Sidney Hecht

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The synthesis of the disaccharide 2-O-(3-O-carbamoyl-α-D-mannopyranosyl)-L-gxuopyranose has been achieved in good yield via the silver triflate promoted coupling of 2,4,6-tri-O-acetyl-3-O-(N-acetylcarbamoyl)-α-D-mannopyranosyl bromide (7) with both benzyl 3,4,6-tri-O-benzyl-β-L-gulopyranoside (5) and 3,4-di-O-benzyl-1,6-anhydro-β-L-gulopyranose (12).

Original languageEnglish (US)
Pages (from-to)3761-3763
Number of pages3
JournalJournal of Organic Chemistry
Volume46
Issue number18
StatePublished - 1981
Externally publishedYes

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Disaccharides
Bleomycin
Bromides
Carbohydrates
trifluoromethanesulfonic acid

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of the carbohydrate moiety of bleomycin. / Pozsgay, Vince; Ohgi, Tadaaki; Hecht, Sidney.

In: Journal of Organic Chemistry, Vol. 46, No. 18, 1981, p. 3761-3763.

Research output: Contribution to journalArticle

Pozsgay, V, Ohgi, T & Hecht, S 1981, 'Synthesis of the carbohydrate moiety of bleomycin', Journal of Organic Chemistry, vol. 46, no. 18, pp. 3761-3763.
Pozsgay, Vince ; Ohgi, Tadaaki ; Hecht, Sidney. / Synthesis of the carbohydrate moiety of bleomycin. In: Journal of Organic Chemistry. 1981 ; Vol. 46, No. 18. pp. 3761-3763.
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