Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Described herein is the preparation of new aminoacylated derivatives of the dinucleotide pdCpA, and of transfer RNAs. The focus of the present work is the synthesis of amino acid analogs related to aspartic acid and cysteine species that have important functional roles in many proteins. The activated aminoacyl-tRNAs prepared can be utilized for the elaboration of proteins containing modified aspartic acid and cysteine derivatives at predetermined sites. Of particular interest is definition of functional group protection strategies that can be used for the preparation of the aminoacylated pdCpAs and tRNAs.

Original languageEnglish (US)
Pages (from-to)9023-9031
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number19
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Keywords

  • Aminoacylation
  • Enzymatic ligation
  • Protein synthesis
  • Sulfur-containing amino acids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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