Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Described herein is the preparation of new aminoacylated derivatives of the dinucleotide pdCpA, and of transfer RNAs. The focus of the present work is the synthesis of amino acid analogs related to aspartic acid and cysteine species that have important functional roles in many proteins. The activated aminoacyl-tRNAs prepared can be utilized for the elaboration of proteins containing modified aspartic acid and cysteine derivatives at predetermined sites. Of particular interest is definition of functional group protection strategies that can be used for the preparation of the aminoacylated pdCpAs and tRNAs.

Original languageEnglish (US)
Pages (from-to)9023-9031
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number19
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Fingerprint

Transfer RNA
Aspartic Acid
Cysteine
Derivatives
Functional groups
Proteins
Amino Acids
5'-phospho-2'-deoxyribocytidylylriboadenosine

Keywords

  • Aminoacylation
  • Enzymatic ligation
  • Protein synthesis
  • Sulfur-containing amino acids

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine. / Chen, Shengxi; Hecht, Sidney.

In: Bioorganic and Medicinal Chemistry, Vol. 16, No. 19, 01.10.2008, p. 9023-9031.

Research output: Contribution to journalArticle

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AB - Described herein is the preparation of new aminoacylated derivatives of the dinucleotide pdCpA, and of transfer RNAs. The focus of the present work is the synthesis of amino acid analogs related to aspartic acid and cysteine species that have important functional roles in many proteins. The activated aminoacyl-tRNAs prepared can be utilized for the elaboration of proteins containing modified aspartic acid and cysteine derivatives at predetermined sites. Of particular interest is definition of functional group protection strategies that can be used for the preparation of the aminoacylated pdCpAs and tRNAs.

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