Synthesis Of (+)-Isocombretastatins A-Cl

Sheo Bux Singh, George Pettit

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

With the African bush willow (Combretum caffrum) constituent R(-)-combretastatin (la) as a model syntheses of iso-combretastatins A(lb), B(1c) AND C(ld) were completed. Reaction (ultrasound promoted) between the lithium derivative of benzyl bromide 2b and silyl protected isovanillin 3a was illustrative of the general synthetic approach. Racemic isocombretastatin A was found to significantly inhibit (ed500.19-0.25μ g/ml) growth of the p388 lymphocytic leukemia cell line.

Original languageEnglish (US)
Pages (from-to)877-892
Number of pages16
JournalSynthetic Communications
Volume17
Issue number7
DOIs
StatePublished - May 1 1987

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Salix
Lithium
Ultrasonics
Cells
Derivatives
combretastatin
isovanillin
benzyl bromide

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis Of (+)-Isocombretastatins A-Cl. / Singh, Sheo Bux; Pettit, George.

In: Synthetic Communications, Vol. 17, No. 7, 01.05.1987, p. 877-892.

Research output: Contribution to journalArticle

Singh, Sheo Bux ; Pettit, George. / Synthesis Of (+)-Isocombretastatins A-Cl. In: Synthetic Communications. 1987 ; Vol. 17, No. 7. pp. 877-892.
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