Synthesis Of (+)-Isocombretastatins A-Cl

Sheo Bux Singh; George Pettit

doi:10.1080/00397918708063944

Synthesis Of (+)-Isocombretastatins A-Cl

Sheo Bux Singh, George Pettit

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

With the African bush willow (Combretum caffrum) constituent R(-)-combretastatin (la) as a model syntheses of iso-combretastatins A(lb), B(1c) AND C(ld) were completed. Reaction (ultrasound promoted) between the lithium derivative of benzyl bromide 2b and silyl protected isovanillin 3a was illustrative of the general synthetic approach. Racemic isocombretastatin A was found to significantly inhibit (ed500.19-0.25μ g/ml) growth of the p388 lymphocytic leukemia cell line.

Original language	English (US)
Pages (from-to)	877-892
Number of pages	16
Journal	Synthetic Communications
Volume	17
Issue number	7
DOIs	https://doi.org/10.1080/00397918708063944
State	Published - May 1 1987

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Organic Chemistry

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10.1080/00397918708063944

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abstract = "With the African bush willow (Combretum caffrum) constituent R(-)-combretastatin (la) as a model syntheses of iso-combretastatins A(lb), B(1c) AND C(ld) were completed. Reaction (ultrasound promoted) between the lithium derivative of benzyl bromide 2b and silyl protected isovanillin 3a was illustrative of the general synthetic approach. Racemic isocombretastatin A was found to significantly inhibit (ed500.19-0.25μ g/ml) growth of the p388 lymphocytic leukemia cell line.",

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AB - With the African bush willow (Combretum caffrum) constituent R(-)-combretastatin (la) as a model syntheses of iso-combretastatins A(lb), B(1c) AND C(ld) were completed. Reaction (ultrasound promoted) between the lithium derivative of benzyl bromide 2b and silyl protected isovanillin 3a was illustrative of the general synthetic approach. Racemic isocombretastatin A was found to significantly inhibit (ed500.19-0.25μ g/ml) growth of the p388 lymphocytic leukemia cell line.

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Synthesis Of (+)-Isocombretastatins A-Cl

Abstract

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