Synthesis of isobufalin methyl ester

T. R. Kasturi; G. R. Pettit; K. A. Jaeggi

doi:10.1039/C19670000644

Synthesis of isobufalin methyl ester

T. R. Kasturi, G. R. Pettit, K. A. Jaeggi

Research output: Contribution to journal › Article › peer-review

Original language	English (US)
Pages (from-to)	644-646
Number of pages	3
Journal	Chemical Communications (London)
Issue number	13
DOIs	https://doi.org/10.1039/C19670000644
State	Published - 1967
Externally published	Yes

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Chemistry(all)

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10.1039/C19670000644

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@article{7f74ccdab448488c889f6b67aa1c562f,

title = "Synthesis of isobufalin methyl ester",

author = "Kasturi, {T. R.} and Pettit, {G. R.} and Jaeggi, {K. A.}",

note = "Funding Information: We now report chemical conversion of digitoxigenin6 into 3~-acetoxyisobufalin methyl ester (IIb) . Con- struction of ester (IIb) confirms the structure and D-ring stereochemistry assigned to bufalin, and represents the first total synthesis to approach so closely a naturally occurring bufadienolide. Digitoxigenin [(111), total synthesis reported in t See ref. 1 for previous paper jn this series. $ All new compounds gave satisfactory elemental analyses. This investigation was supported by Public Health Service Grants Optical rotations were measured in CHC1, and U.V. ",

year = "1967",

doi = "10.1039/C19670000644",

language = "English (US)",

pages = "644--646",

journal = "Chemical Communications (London)",

issn = "0009-241X",

number = "13",

}

TY - JOUR

T1 - Synthesis of isobufalin methyl ester

AU - Kasturi, T. R.

AU - Pettit, G. R.

AU - Jaeggi, K. A.

N1 - Funding Information: We now report chemical conversion of digitoxigenin6 into 3~-acetoxyisobufalin methyl ester (IIb) . Con- struction of ester (IIb) confirms the structure and D-ring stereochemistry assigned to bufalin, and represents the first total synthesis to approach so closely a naturally occurring bufadienolide. Digitoxigenin [(111), total synthesis reported in t See ref. 1 for previous paper jn this series. $ All new compounds gave satisfactory elemental analyses. This investigation was supported by Public Health Service Grants Optical rotations were measured in CHC1, and U.V.

PY - 1967

Y1 - 1967

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UR - http://www.scopus.com/inward/citedby.url?scp=37049142105&partnerID=8YFLogxK

U2 - 10.1039/C19670000644

DO - 10.1039/C19670000644

M3 - Article

AN - SCOPUS:37049142105

SN - 0009-241X

SP - 644

EP - 646

JO - Chemical Communications (London)

JF - Chemical Communications (London)

IS - 13

ER -

Synthesis of isobufalin methyl ester

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