Synthesis of cationic polymer libraries for gene delivery using diglycidyl ethers

Jacob Elmer, Thrimoorthy Potta, Kaushal Rege

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gene therapy has the potential to cure many different genetic diseases, if safe and effective gene delivery vectors can be developed. This chapter describes protocols for the synthesis of novel polymers using diglycidyl ether and diamine or polyamine monomers for transgene delivery and expression. The resulting poly (amino ethers) are able to transfect a higher number of cells, with lower cytotoxicity than other commercially available polymers (e.g., Polyethyleneimine, PEI).

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages3-16
Number of pages14
DOIs
StatePublished - Jan 1 2018

Publication series

NameMethods in Molecular Biology
Volume1831
ISSN (Print)1064-3745

Keywords

  • Aminoglycosides
  • Diglycidyl ethers
  • Gene delivery
  • Gene therapy
  • Polymers
  • Polyplex

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Elmer, J., Potta, T., & Rege, K. (2018). Synthesis of cationic polymer libraries for gene delivery using diglycidyl ethers. In Methods in Molecular Biology (pp. 3-16). (Methods in Molecular Biology; Vol. 1831). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8661-3_1