Synthesis of a potent and selective inhibitor of p90 Rsk

David J. Maloney; Sidney M. Hecht

doi:10.1021/ol0500463

Synthesis of a potent and selective inhibitor of p90 Rsk

David J. Maloney, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

(Chemical Equation Presented) The synthesis of the naturally occurring kaempferol glycoside SL0101 has been accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.

Original language	English (US)
Pages (from-to)	1097-1099
Number of pages	3
Journal	Organic Letters
Volume	7
Issue number	6
DOIs	https://doi.org/10.1021/ol0500463
State	Published - Mar 17 2005
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0500463

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title = "Synthesis of a potent and selective inhibitor of p90 Rsk",

abstract = "(Chemical Equation Presented) The synthesis of the naturally occurring kaempferol glycoside SL0101 has been accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.",

author = "Maloney, {David J.} and Hecht, {Sidney M.}",

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AU - Hecht, Sidney M.

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N2 - (Chemical Equation Presented) The synthesis of the naturally occurring kaempferol glycoside SL0101 has been accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.

AB - (Chemical Equation Presented) The synthesis of the naturally occurring kaempferol glycoside SL0101 has been accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.

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JO - Organic Letters

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Synthesis of a potent and selective inhibitor of p90 Rsk

Abstract

ASJC Scopus subject areas

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