Synthesis of a potent and selective inhibitor of p90 Rsk

David J. Maloney, Sidney M. Hecht

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

(Chemical Equation Presented) The synthesis of the naturally occurring kaempferol glycoside SL0101 has been accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.

Original languageEnglish (US)
Pages (from-to)1097-1099
Number of pages3
JournalOrganic Letters
Volume7
Issue number6
DOIs
StatePublished - Mar 17 2005

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this