Synthesis of a potent and selective inhibitor of p90 Rsk

David J. Maloney, Sidney Hecht

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

(Chemical Equation Presented) The synthesis of the naturally occurring kaempferol glycoside SL0101 has been accomplished, as has its biochemical evaluation. SL0101 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthesis verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.

Original languageEnglish (US)
Pages (from-to)1097-1099
Number of pages3
JournalOrganic Letters
Volume7
Issue number6
DOIs
StatePublished - Mar 17 2005
Externally publishedYes

Fingerprint

90-kDa Ribosomal Protein S6 Kinases
inhibitors
glucosides
evaluation
Mitogen-Activated Protein Kinase Kinases
synthesis
Glycosides
Biological Products
upstream
Phosphotransferases
products
SL0101

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Synthesis of a potent and selective inhibitor of p90 Rsk. / Maloney, David J.; Hecht, Sidney.

In: Organic Letters, Vol. 7, No. 6, 17.03.2005, p. 1097-1099.

Research output: Contribution to journalArticle

Maloney, David J. ; Hecht, Sidney. / Synthesis of a potent and selective inhibitor of p90 Rsk. In: Organic Letters. 2005 ; Vol. 7, No. 6. pp. 1097-1099.
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