Abstract
(Chemical Equation Presented) 14-Azacamptothecin, a potent, water-soluble analogue of the antitumor agent camptothecin, has been prepared by a convergent synthesis. The key condensation of the AB and DE rings with concomitant formation of ring C of 14-aza CPT was carried out in two stages, the latter of which involved a radical cyclization strategy.
Original language | English (US) |
---|---|
Pages (from-to) | 835-837 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 5 |
DOIs | |
State | Published - Mar 3 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry