Synthesis, characterization and application of biodegradable polymer grafted novel bioprosthetic tissue

Amrita Pal, Chandrashekhar Pathak, Brent Vernon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Animal tissue has an extended history of clinical use in applications like heart valve bioprosthesis devices, cardiovascular surgical applications etc. but often does not last long after implantation in the body due to rapid unwanted degradation. The goal of this work is to develop novel composite biomaterials by grafting biological tissue with synthetic, biodegradable polymers. In the current research phase, porcine submucosa, ureter and bovine pericardial tissue are grafted with poly DL-lactide (PLA), poly glycolide (PGA) and poly DL-lactide glycolide (PLGA) copolymers. The grafted and control tissues are characterized by FTIR and SEM. The biodegradability of the tissue-graft composite materials is determined by pepsin and collagenase digestion assays, showing it can be tailored by varying the grafted polymer type and amount. The grafted tissues can be tuned for a particular clinical or tissue engineering applications including drug delivery with little or no burst release and sustained/controlled delivery.

Original languageEnglish (US)
Pages (from-to)217-235
Number of pages19
JournalJournal of Biomaterials Science, Polymer Edition
Volume29
Issue number3
DOIs
StatePublished - Feb 11 2018

Fingerprint

Biodegradable polymers
Polymers
Tissue
Prostaglandins A
Biomedical Engineering
Bioprosthesis
Tissue Transplantation
Heart Valves
Biocompatible Materials
Collagenases
Fourier Transform Infrared Spectroscopy
Tissue Engineering
Ureter
Digestion
Swine
Biodegradability
Composite materials
Transplants
Tissue engineering
Biomaterials

Keywords

  • Biodegradable polymers
  • drug delivery
  • FTIR
  • SEM
  • tissue grafting

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Synthesis, characterization and application of biodegradable polymer grafted novel bioprosthetic tissue. / Pal, Amrita; Pathak, Chandrashekhar; Vernon, Brent.

In: Journal of Biomaterials Science, Polymer Edition, Vol. 29, No. 3, 11.02.2018, p. 217-235.

Research output: Contribution to journalArticle

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