Sintez i issledovanie biologicheskoi aktivnosti stereoizomernykh dipeptidov, soderzhashchikh ostatki tirozina i arginina.

Translated title of the contribution: Synthesis and study of biological activity of stereoisomeric dipeptides containing tyrosine and arginine residues

S. A. Poiarkova, V. A. Bezmenova, T. P. Ugarova, V. K. Kibirev, L. A. Gromov

Research output: Contribution to journalArticle

Abstract

Series of methyl esters of stereoisomeric dipeptides of the sequences Tyr-Arg and Arg-Tyr has been synthesized by classic methods of the peptide chemistry. The study of their reactivity towards thrombin and trypsin has shown that the kinetic parameters of enzyme-catalyzed hydrolyses of stereoisomeric compounds differ in values essentially. Testing the synthetic peptides on analgic effect, on inhibition of the reaction fibrinogen with thrombin or on influence upon the process of fibrin-monomer polymerization has shown that these biological effects depend on peptide structure and on configuration of amino acid residues forming the peptides.

Original languageUndefined/Unknown
Pages (from-to)14-19
Number of pages6
JournalUkrainskii biokhimicheskii zhurnal
Volume71
Issue number2
StatePublished - Mar 1999
Externally publishedYes

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Dipeptides
Bioactivity
Tyrosine
Arginine
Peptides
Thrombin
kyotorphin
Kinetic parameters
Polymerization
Trypsin
Fibrinogen
Hydrolysis
Esters
Amino Acids
Testing
Enzymes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Sintez i issledovanie biologicheskoi aktivnosti stereoizomernykh dipeptidov, soderzhashchikh ostatki tirozina i arginina. / Poiarkova, S. A.; Bezmenova, V. A.; Ugarova, T. P.; Kibirev, V. K.; Gromov, L. A.

In: Ukrainskii biokhimicheskii zhurnal, Vol. 71, No. 2, 03.1999, p. 14-19.

Research output: Contribution to journalArticle

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