Synthesis and study of biological activity of stereoisomeric dipeptides, containing the residues of tyrosine and arginine

S. A. Poyarkova, V. A. Bezmenova, T. P. Ugarova, V. K. Kibirev, L. A. Gromov

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Series of methyl esters of stereoisomeric dipeptides of the sequences Tyr-Arg and Arg-Tyr has been synthesized by classic methods of the peptide chemistry. The study of their reactivity towards thrombin and trypsin has shown that the kinetic parameters of enzyme-catalyzed hydrolyses of stereoisomeric compounds differ in values essentially. Testing the synthetic peptides on analgic effect, on inhibition of the reaction fibrinogen with thrombin or on influence upon the process of fibrin-monomer polymerization has shown that these biological effects depend on peptide structure and on configuration of amino acid residues forming the peptides.

Original languageEnglish (US)
Pages (from-to)18-19
Number of pages2
JournalUkrain'skyi Biokhimichnyi Zhurnal
Volume71
Issue number2
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Analgetic effect
  • Inhibitors
  • Peptides
  • Substrat
  • Thrombin
  • Trypsin

ASJC Scopus subject areas

  • Biochemistry

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