Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains

Amos B. Smith; Qiyan Lin; George Pettit; Jean Chapuis; Jean M. Schmidt

doi:10.1016/S0960-894X(98)00050-X

Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains

Amos B. Smith, Qiyan Lin, George Pettit, Jean Chapuis, Jean M. Schmidt

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Two monosaccharides embodying triene side-chains of the spongistatins display significant in vitro activity against human cancer cell lines.

Original language	English (US)
Pages (from-to)	567-568
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(98)00050-X
State	Published - Mar 17 1998

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(98)00050-X

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title = "Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains",

abstract = "Two monosaccharides embodying triene side-chains of the spongistatins display significant in vitro activity against human cancer cell lines.",

author = "Smith, {Amos B.} and Qiyan Lin and George Pettit and Jean Chapuis and Schmidt, {Jean M.}",

note = "Funding Information: Acknowledgments. Financial support was provided by the National Institutes of Health (National Cancer Institute, grant CA-70329), SmithKline Beecham, DuPont Merck Pharmaceutical Co., and Zeneca Inc.",

year = "1998",

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T1 - Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains

AU - Smith, Amos B.

AU - Lin, Qiyan

AU - Pettit, George

AU - Chapuis, Jean

AU - Schmidt, Jean M.

N1 - Funding Information: Acknowledgments. Financial support was provided by the National Institutes of Health (National Cancer Institute, grant CA-70329), SmithKline Beecham, DuPont Merck Pharmaceutical Co., and Zeneca Inc.

PY - 1998/3/17

Y1 - 1998/3/17

N2 - Two monosaccharides embodying triene side-chains of the spongistatins display significant in vitro activity against human cancer cell lines.

AB - Two monosaccharides embodying triene side-chains of the spongistatins display significant in vitro activity against human cancer cell lines.

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AN - SCOPUS:0032539886

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Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains

Abstract

ASJC Scopus subject areas

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