Synthesis and DNA cleavage activity of a novel bleomycin A5 glycoconjugate

Ambar K. Choudhury, Zhi Fu Tao, Sidney M. Hecht

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

(equation presented) To explore the possibility of modifying bleomycin in a fashion that could alter its physiological distribution in a therapeutic setting, a new analogue of bleomycin has been prepared. This analogue is intended to target the asialoglycoprotein receptor on liver cells. Critically, despite the large C-substituent, the bleomycin conjugate was found to degrade DNA in the same fashion as bleomycin A5 itself, and with only modestly decreased efficiency.

Original languageEnglish (US)
Pages (from-to)1291-1294
Number of pages4
JournalOrganic Letters
Volume3
Issue number9
DOIs
StatePublished - May 3 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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