Abstract
(equation presented) To explore the possibility of modifying bleomycin in a fashion that could alter its physiological distribution in a therapeutic setting, a new analogue of bleomycin has been prepared. This analogue is intended to target the asialoglycoprotein receptor on liver cells. Critically, despite the large C-substituent, the bleomycin conjugate was found to degrade DNA in the same fashion as bleomycin A5 itself, and with only modestly decreased efficiency.
Original language | English (US) |
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Pages (from-to) | 1291-1294 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 3 |
Issue number | 9 |
DOIs | |
State | Published - May 3 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry