Synthesis and characterization of radio-opaque thermosensitive poly N-isopropylacrylamide-2,2′-(ethylenedioxy)bis (ethylamine)-2,3,5-triiodobenzamide

Christine M. Leon, Bae Hoon Lee, Mark Preul, Ryan McLemore, Brent Vernon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: In situ gelling polymers, like poly(N-isopropylacrylamide) (poly(NIPAAm)), have many potential medical applications due to their biocompatibility and thermosensitivity. Results: Radio-opaque thermosensitive poly(NIPAAm) grafted with 10.7 wt% 2,2′-(ethylenedioxy)bis(ethylamine)-2,3,5- triiodobenzamide was successfully synthesized and characterized. The conjugated polymer showed good visibility with X-ray fluoroscopy. The polymer had a lower critical solution temperature of 30 °C after conjugation with triiodobenzamide as determined by cloud point determination and a transition peak temperature of 33.3 ± 0.57 °C as determined by differential scanning calorimetry. Conclusion: The polymer synthesized was highly visible under X-rays, based upon the percentage incorporation of triiodobenzamide. After conjugation of the NIPAAm to the triiodobenzamide through a bis(ethylamine) linkage, the resultant polymer retained lower critical solution temperature characteristics in a temperature region that makes it physiologically useful.

Original languageEnglish (US)
Pages (from-to)847-850
Number of pages4
JournalPolymer International
Volume58
Issue number8
DOIs
StatePublished - 2009

Fingerprint

Polymers
X rays
Temperature
Conjugated polymers
Medical applications
Biocompatibility
Visibility
Differential scanning calorimetry
ethylamine
Radio-Opaque acrylic resin
poly-N-isopropylacrylamide

Keywords

  • Lower critical solution temperature (LCST)
  • N-isopropylacrylamide (NIPAAm)
  • Radio-opaque
  • Thermosensitive

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Synthesis and characterization of radio-opaque thermosensitive poly N-isopropylacrylamide-2,2′-(ethylenedioxy)bis (ethylamine)-2,3,5-triiodobenzamide. / Leon, Christine M.; Lee, Bae Hoon; Preul, Mark; McLemore, Ryan; Vernon, Brent.

In: Polymer International, Vol. 58, No. 8, 2009, p. 847-850.

Research output: Contribution to journalArticle

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abstract = "Background: In situ gelling polymers, like poly(N-isopropylacrylamide) (poly(NIPAAm)), have many potential medical applications due to their biocompatibility and thermosensitivity. Results: Radio-opaque thermosensitive poly(NIPAAm) grafted with 10.7 wt{\%} 2,2′-(ethylenedioxy)bis(ethylamine)-2,3,5- triiodobenzamide was successfully synthesized and characterized. The conjugated polymer showed good visibility with X-ray fluoroscopy. The polymer had a lower critical solution temperature of 30 °C after conjugation with triiodobenzamide as determined by cloud point determination and a transition peak temperature of 33.3 ± 0.57 °C as determined by differential scanning calorimetry. Conclusion: The polymer synthesized was highly visible under X-rays, based upon the percentage incorporation of triiodobenzamide. After conjugation of the NIPAAm to the triiodobenzamide through a bis(ethylamine) linkage, the resultant polymer retained lower critical solution temperature characteristics in a temperature region that makes it physiologically useful.",
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AU - Leon, Christine M.

AU - Lee, Bae Hoon

AU - Preul, Mark

AU - McLemore, Ryan

AU - Vernon, Brent

PY - 2009

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N2 - Background: In situ gelling polymers, like poly(N-isopropylacrylamide) (poly(NIPAAm)), have many potential medical applications due to their biocompatibility and thermosensitivity. Results: Radio-opaque thermosensitive poly(NIPAAm) grafted with 10.7 wt% 2,2′-(ethylenedioxy)bis(ethylamine)-2,3,5- triiodobenzamide was successfully synthesized and characterized. The conjugated polymer showed good visibility with X-ray fluoroscopy. The polymer had a lower critical solution temperature of 30 °C after conjugation with triiodobenzamide as determined by cloud point determination and a transition peak temperature of 33.3 ± 0.57 °C as determined by differential scanning calorimetry. Conclusion: The polymer synthesized was highly visible under X-rays, based upon the percentage incorporation of triiodobenzamide. After conjugation of the NIPAAm to the triiodobenzamide through a bis(ethylamine) linkage, the resultant polymer retained lower critical solution temperature characteristics in a temperature region that makes it physiologically useful.

AB - Background: In situ gelling polymers, like poly(N-isopropylacrylamide) (poly(NIPAAm)), have many potential medical applications due to their biocompatibility and thermosensitivity. Results: Radio-opaque thermosensitive poly(NIPAAm) grafted with 10.7 wt% 2,2′-(ethylenedioxy)bis(ethylamine)-2,3,5- triiodobenzamide was successfully synthesized and characterized. The conjugated polymer showed good visibility with X-ray fluoroscopy. The polymer had a lower critical solution temperature of 30 °C after conjugation with triiodobenzamide as determined by cloud point determination and a transition peak temperature of 33.3 ± 0.57 °C as determined by differential scanning calorimetry. Conclusion: The polymer synthesized was highly visible under X-rays, based upon the percentage incorporation of triiodobenzamide. After conjugation of the NIPAAm to the triiodobenzamide through a bis(ethylamine) linkage, the resultant polymer retained lower critical solution temperature characteristics in a temperature region that makes it physiologically useful.

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KW - N-isopropylacrylamide (NIPAAm)

KW - Radio-opaque

KW - Thermosensitive

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