Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications

Naomi Joseph, Harrison D. Lawson, Kalon J. Overholt, Krishnan Damodaran, Riccardo Gottardi, Abhinav P. Acharya, Steven R. Little

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Abstract

Metal-organic frameworks (MOFs) formed from metals and organic ligands, are crystalline materials that are degradable in aqueous medium, and capable of releasing Ca and Sr ions. In this manuscript, the ability of MOFs to degrade and release osteogenic Ca and Sr ions was investigated. MOFs were generated by choosing osteoinductive Ca and Sr metals, and an organic ligand 1,3,5 tricarboxylicbenzene (H3BTC) as a linker. These MOFs were able to induce in vitro biomineralization from pre-osteoblastic MC3T3 cells and human mesenchymal stem cells (hMSCs). Moreover, these MOFs (when loaded with dimethyloxalylglycine (DMOG)) induced vascular endothelial production from hMSCs. qRT-PCR analysis performed on hMSCs (isolated from femoral heads of patients undergoing joint arthroplasty) treated with MOFs crystals suggested that the CaSr-MOFs by themselves can upregulate osteogenic genes in hMSCs, which is the first time to our knowledge that this has been observed from MOFs.

Original languageEnglish (US)
Article number13024
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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