Synthesis and biological evaluation of fully synthetic bryostatin analogues

Paul A. Wender, Jef De Brabander, Patrick G. Harran, Kevin W. Hinkle, Blaise Lippa, George Pettit

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)8625-8628
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number47
DOIs
StatePublished - Nov 19 1998

Fingerprint

Bryostatins
Protein Kinase C
Cells
Cell Line
Growth
Neoplasms
bryostatin 1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Wender, P. A., De Brabander, J., Harran, P. G., Hinkle, K. W., Lippa, B., & Pettit, G. (1998). Synthesis and biological evaluation of fully synthetic bryostatin analogues. Tetrahedron Letters, 39(47), 8625-8628. https://doi.org/10.1016/S0040-4039(98)01955-8

Synthesis and biological evaluation of fully synthetic bryostatin analogues. / Wender, Paul A.; De Brabander, Jef; Harran, Patrick G.; Hinkle, Kevin W.; Lippa, Blaise; Pettit, George.

In: Tetrahedron Letters, Vol. 39, No. 47, 19.11.1998, p. 8625-8628.

Research output: Contribution to journalArticle

Wender, PA, De Brabander, J, Harran, PG, Hinkle, KW, Lippa, B & Pettit, G 1998, 'Synthesis and biological evaluation of fully synthetic bryostatin analogues', Tetrahedron Letters, vol. 39, no. 47, pp. 8625-8628. https://doi.org/10.1016/S0040-4039(98)01955-8
Wender, Paul A. ; De Brabander, Jef ; Harran, Patrick G. ; Hinkle, Kevin W. ; Lippa, Blaise ; Pettit, George. / Synthesis and biological evaluation of fully synthetic bryostatin analogues. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 47. pp. 8625-8628.
@article{53c046459447487ba8d05f45de1919ac,
title = "Synthesis and biological evaluation of fully synthetic bryostatin analogues",
abstract = "The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines.",
author = "Wender, {Paul A.} and {De Brabander}, Jef and Harran, {Patrick G.} and Hinkle, {Kevin W.} and Blaise Lippa and George Pettit",
year = "1998",
month = "11",
day = "19",
doi = "10.1016/S0040-4039(98)01955-8",
language = "English (US)",
volume = "39",
pages = "8625--8628",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "47",

}

TY - JOUR

T1 - Synthesis and biological evaluation of fully synthetic bryostatin analogues

AU - Wender, Paul A.

AU - De Brabander, Jef

AU - Harran, Patrick G.

AU - Hinkle, Kevin W.

AU - Lippa, Blaise

AU - Pettit, George

PY - 1998/11/19

Y1 - 1998/11/19

N2 - The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines.

AB - The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines.

UR - http://www.scopus.com/inward/record.url?scp=0032547979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032547979&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(98)01955-8

DO - 10.1016/S0040-4039(98)01955-8

M3 - Article

AN - SCOPUS:0032547979

VL - 39

SP - 8625

EP - 8628

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 47

ER -