10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Aug 3 2006|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry