Synthesis and biological evaluation of 10,11-methylenedioxy-14- azacamptothecin

Mark A. Elban, Wenyue Sun, Brian M. Eisenhauer, Rong Gao, Sidney M. Hecht

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification.

Original languageEnglish (US)
Pages (from-to)3513-3516
Number of pages4
JournalOrganic Letters
Volume8
Issue number16
DOIs
StatePublished - Aug 3 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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