Synthesis and biological activity of some structural modifications of pancratistatin

Uwe Rinner; Heather L. Hillebrenner; David R. Adams; Tomas Hudlicky; George Pettit

doi:10.1016/j.bmcl.2004.03.032

Synthesis and biological activity of some structural modifications of pancratistatin

Uwe Rinner, Heather L. Hillebrenner, David R. Adams, Tomas Hudlicky, George Pettit

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.

Original language	English (US)
Pages (from-to)	2911-2915
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2004.03.032
State	Published - Jun 7 2004

Keywords

Amaryllidaceae alkaloids
Anticancer drugs
Enantioselective synthesis
Pancratistatin

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Synthesis and biological activity of some structural modifications of pancratistatin",

abstract = "Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.",

keywords = "Amaryllidaceae alkaloids, Anticancer drugs, Enantioselective synthesis, Pancratistatin",

author = "Uwe Rinner and Hillebrenner, {Heather L.} and Adams, {David R.} and Tomas Hudlicky and George Pettit",

year = "2004",

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AU - Adams, David R.

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AU - Pettit, George

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KW - Enantioselective synthesis

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