Synthesis and biological activity of some structural modifications of pancratistatin

Uwe Rinner; Heather L. Hillebrenner; David R. Adams; Tomas Hudlicky; George Pettit

doi:10.1016/j.bmcl.2004.03.032

Synthesis and biological activity of some structural modifications of pancratistatin

Uwe Rinner, Heather L. Hillebrenner, David R. Adams, Tomas Hudlicky, George Pettit

Research output: Contribution to journal › Article

78 Scopus citations

Abstract

Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.

Original language	English (US)
Pages (from-to)	2911-2915
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2004.03.032
State	Published - Jun 7 2004

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Keywords

Amaryllidaceae alkaloids
Anticancer drugs
Enantioselective synthesis
Pancratistatin

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Cite this

Rinner, U., Hillebrenner, H. L., Adams, D. R., Hudlicky, T., & Pettit, G. (2004). Synthesis and biological activity of some structural modifications of pancratistatin. Bioorganic and Medicinal Chemistry Letters, 14(11), 2911-2915. https://doi.org/10.1016/j.bmcl.2004.03.032

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abstract = "Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.",

keywords = "Amaryllidaceae alkaloids, Anticancer drugs, Enantioselective synthesis, Pancratistatin",

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Access to Document

10.1016/j.bmcl.2004.03.032