Synthesis and biochemical properties of E-ring modified luotonin a derivatives

Ali Cagir, Shannon H. Jones, Brian M. Eisenhauer, Rong Gao, Sidney M. Hecht

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.

Original languageEnglish (US)
Pages (from-to)2051-2054
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number9
DOIs
StatePublished - May 3 2004

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Keywords

  • Antineoplastic agents
  • Cytotoxic alkaloids
  • Topoisomerase I poisons

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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