Abstract
In order to achieve bone repair, bone morphogenetic protein-2 (BMP-2) is typically delivered in non-physiological doses and can result in significant adverse side effects. To reduce the amount of BMP-2 necessary for bone formation, we delivered a known chemokine (stromal cell derived factor-1α, SDF-1α) in combination with BMP-2 using proteolytically degradable hydrogels. A critical-sized calvarial defect was used to determine the effect of biomolecule delivery on bone formation in vivo. The treatment group with combined SDF-1α and BMP-2 hydrogel delivery showed significantly higher bone formation when compared to hydrogels loaded with the same BMP-2 or SDF-1α concentrations alone, suggesting the combined delivery of both biomolecules synergistically improves osteogenesis.
Original language | English (US) |
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Pages (from-to) | 1218-1223 |
Number of pages | 6 |
Journal | Macromolecular Bioscience |
Volume | 15 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2015 |
Externally published | Yes |
Keywords
- bone morphogenetic protein
- bone tissue engineering
- drug delivery
- hyaluronic acid
- hydrogel
- stromal cell-derived factor-1α
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomaterials
- Polymers and Plastics
- Materials Chemistry