Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair

Julianne Holloway, Henry Ma, Reena Rai, Kurt D. Hankenson, Jason A. Burdick

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In order to achieve bone repair, bone morphogenetic protein-2 (BMP-2) is typically delivered in non-physiological doses and can result in significant adverse side effects. To reduce the amount of BMP-2 necessary for bone formation, we delivered a known chemokine (stromal cell derived factor-1α, SDF-1α) in combination with BMP-2 using proteolytically degradable hydrogels. A critical-sized calvarial defect was used to determine the effect of biomolecule delivery on bone formation in vivo. The treatment group with combined SDF-1α and BMP-2 hydrogel delivery showed significantly higher bone formation when compared to hydrogels loaded with the same BMP-2 or SDF-1α concentrations alone, suggesting the combined delivery of both biomolecules synergistically improves osteogenesis.

Original languageEnglish (US)
Pages (from-to)1218-1223
Number of pages6
JournalMacromolecular Bioscience
Volume15
Issue number9
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Fingerprint

Chemokine CXCL12
Hyaluronic acid
Bone Morphogenetic Protein 2
Hydrogels
Hyaluronic Acid
Bone
Repair
Osteogenesis
Proteins
Bone and Bones
Biomolecules
Hydrogel
Chemokines
Defects

Keywords

  • bone morphogenetic protein
  • bone tissue engineering
  • drug delivery
  • hyaluronic acid
  • hydrogel
  • stromal cell-derived factor-1α

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair. / Holloway, Julianne; Ma, Henry; Rai, Reena; Hankenson, Kurt D.; Burdick, Jason A.

In: Macromolecular Bioscience, Vol. 15, No. 9, 01.09.2015, p. 1218-1223.

Research output: Contribution to journalArticle

Holloway, Julianne ; Ma, Henry ; Rai, Reena ; Hankenson, Kurt D. ; Burdick, Jason A. / Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair. In: Macromolecular Bioscience. 2015 ; Vol. 15, No. 9. pp. 1218-1223.
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