Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair

Julianne L. Holloway; Henry Ma; Reena Rai; Kurt D. Hankenson; Jason A. Burdick

doi:10.1002/mabi.201500178

Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair

Julianne L. Holloway, Henry Ma, Reena Rai, Kurt D. Hankenson, Jason A. Burdick

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

In order to achieve bone repair, bone morphogenetic protein-2 (BMP-2) is typically delivered in non-physiological doses and can result in significant adverse side effects. To reduce the amount of BMP-2 necessary for bone formation, we delivered a known chemokine (stromal cell derived factor-1α, SDF-1α) in combination with BMP-2 using proteolytically degradable hydrogels. A critical-sized calvarial defect was used to determine the effect of biomolecule delivery on bone formation in vivo. The treatment group with combined SDF-1α and BMP-2 hydrogel delivery showed significantly higher bone formation when compared to hydrogels loaded with the same BMP-2 or SDF-1α concentrations alone, suggesting the combined delivery of both biomolecules synergistically improves osteogenesis.

Original language	English (US)
Pages (from-to)	1218-1223
Number of pages	6
Journal	Macromolecular Bioscience
Volume	15
Issue number	9
DOIs	https://doi.org/10.1002/mabi.201500178
State	Published - Sep 1 2015
Externally published	Yes

Keywords

bone morphogenetic protein
bone tissue engineering
drug delivery
hyaluronic acid
hydrogel
stromal cell-derived factor-1α

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1002/mabi.201500178

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abstract = "In order to achieve bone repair, bone morphogenetic protein-2 (BMP-2) is typically delivered in non-physiological doses and can result in significant adverse side effects. To reduce the amount of BMP-2 necessary for bone formation, we delivered a known chemokine (stromal cell derived factor-1α, SDF-1α) in combination with BMP-2 using proteolytically degradable hydrogels. A critical-sized calvarial defect was used to determine the effect of biomolecule delivery on bone formation in vivo. The treatment group with combined SDF-1α and BMP-2 hydrogel delivery showed significantly higher bone formation when compared to hydrogels loaded with the same BMP-2 or SDF-1α concentrations alone, suggesting the combined delivery of both biomolecules synergistically improves osteogenesis.",

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AU - Holloway, Julianne L.

AU - Ma, Henry

AU - Rai, Reena

AU - Hankenson, Kurt D.

AU - Burdick, Jason A.

PY - 2015/9/1

Y1 - 2015/9/1

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KW - bone morphogenetic protein

KW - bone tissue engineering

KW - drug delivery

KW - hyaluronic acid

KW - hydrogel

KW - stromal cell-derived factor-1α

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Synergistic Effects of SDF-1α and BMP-2 Delivery from Proteolytically Degradable Hyaluronic Acid Hydrogels for Bone Repair

Abstract

Keywords

ASJC Scopus subject areas

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