Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation

Chen Li, Ning Zhu, Heather N. Emady, Lifeng Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size and hydrophilicity, show significant influence on the dynamic granulation process and the final granular product.

Original languageEnglish (US)
Title of host publicationCFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology
EditorsXiaotao Bi, Cedric Briens, Naoko Ellis, Michael Wormsbecker
PublisherGLAB Reactor and Fluidization Technologies
Pages333-338
Number of pages6
ISBN (Electronic)9781771368506
StatePublished - 2021
Externally publishedYes
Event13th International Conference on Fluidized Bed Technology, CFB 2021 - Vancouver, Canada
Duration: May 10 2021May 14 2021

Publication series

NameCFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology

Conference

Conference13th International Conference on Fluidized Bed Technology, CFB 2021
Country/TerritoryCanada
CityVancouver
Period5/10/215/14/21

ASJC Scopus subject areas

  • Filtration and Separation
  • Fluid Flow and Transfer Processes
  • Energy Engineering and Power Technology
  • Control and Systems Engineering

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