Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation

Chen Li; Ning Zhu; Heather N. Emady; Lifeng Zhang

Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation

Chen Li, Ning Zhu, Heather N. Emady, Lifeng Zhang

Engineering, Ira A. Fulton Schools of (IAFSE)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size and hydrophilicity, show significant influence on the dynamic granulation process and the final granular product.

Original language	English (US)
Title of host publication	CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology
Editors	Xiaotao Bi, Cedric Briens, Naoko Ellis, Michael Wormsbecker
Publisher	GLAB Reactor and Fluidization Technologies
Pages	333-338
Number of pages	6
ISBN (Electronic)	9781771368506
State	Published - 2021
Event	13th International Conference on Fluidized Bed Technology, CFB 2021 - Vancouver, Canada Duration: May 10 2021 → May 14 2021

Publication series

Name	CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology

Conference

Conference	13th International Conference on Fluidized Bed Technology, CFB 2021
Country/Territory	Canada
City	Vancouver
Period	5/10/21 → 5/14/21

ASJC Scopus subject areas

Filtration and Separation
Fluid Flow and Transfer Processes
Energy Engineering and Power Technology
Control and Systems Engineering

Cite this

Li, C., Zhu, N., Emady, H. N., & Zhang, L. (2021). Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation. In X. Bi, C. Briens, N. Ellis, & M. Wormsbecker (Eds.), CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology (pp. 333-338). (CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology). GLAB Reactor and Fluidization Technologies.

Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation. / Li, Chen; Zhu, Ning; Emady, Heather N. et al.
CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology. ed. / Xiaotao Bi; Cedric Briens; Naoko Ellis; Michael Wormsbecker. GLAB Reactor and Fluidization Technologies, 2021. p. 333-338 (CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Li, C, Zhu, N, Emady, HN & Zhang, L 2021, Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation. in X Bi, C Briens, N Ellis & M Wormsbecker (eds), CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology. CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology, GLAB Reactor and Fluidization Technologies, pp. 333-338, 13th International Conference on Fluidized Bed Technology, CFB 2021, Vancouver, Canada, 5/10/21.

Li C, Zhu N, Emady HN, Zhang L. Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation. In Bi X, Briens C, Ellis N, Wormsbecker M, editors, CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology. GLAB Reactor and Fluidization Technologies. 2021. p. 333-338. (CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology).

Li, Chen ; Zhu, Ning ; Emady, Heather N. et al. / Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation. CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology. editor / Xiaotao Bi ; Cedric Briens ; Naoko Ellis ; Michael Wormsbecker. GLAB Reactor and Fluidization Technologies, 2021. pp. 333-338 (CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology).

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abstract = "Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size and hydrophilicity, show significant influence on the dynamic granulation process and the final granular product.",

author = "Chen Li and Ning Zhu and Emady, {Heather N.} and Lifeng Zhang",

note = "Publisher Copyright: {\textcopyright} 2021 CFB 2021 - Proceedings of the 13th International Conference on Fluidized Bed Technology. All rights reserved.; 13th International Conference on Fluidized Bed Technology, CFB 2021 ; Conference date: 10-05-2021 Through 14-05-2021",

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N2 - Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size and hydrophilicity, show significant influence on the dynamic granulation process and the final granular product.

AB - Wet granulation of powders is a key unit operation in the pharmaceutical industry. Due to the complexity of the granulation process taking place in a short time, observing and measuring the granulation process is challenging with conventional experimental methods. In this study, synchrotron-based X-ray imaging techniques were, for the first time, employed to capture the dynamic granulation process with a single drop impacting method in pharmaceutical powder beds. Five common pharmaceutical excipients, two active pharmaceutical ingredients (APIs) and their mixtures were used as the powder beds. The dynamic interaction between the liquid binder and solid powders were observed from high resolution X-ray images captured. Results show that pharmaceutical powder properties, including particle size and hydrophilicity, show significant influence on the dynamic granulation process and the final granular product.

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Synchrotron-based X-ray in-situ imaging techniques for advancing the understanding of pharmaceutical granulation

Abstract

Publication series

Conference

ASJC Scopus subject areas

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