Synaptic slaughter in Alzheimer's disease

Paul D. Coleman, Pamela J. Yao

Research output: Contribution to journalArticlepeer-review

296 Scopus citations

Abstract

Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer's disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking.

Original languageEnglish (US)
Pages (from-to)1023-1027
Number of pages5
JournalNeurobiology of Aging
Volume24
Issue number8
DOIs
StatePublished - Dec 2003
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Gene expression profiling
  • Neurofibrillary tangles
  • Synapses
  • Synaptic vesicle trafficking

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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