Abstract
Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer's disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking.
Original language | English (US) |
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Pages (from-to) | 1023-1027 |
Number of pages | 5 |
Journal | Neurobiology of Aging |
Volume | 24 |
Issue number | 8 |
DOIs | |
State | Published - Dec 2003 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Gene expression profiling
- Neurofibrillary tangles
- Synapses
- Synaptic vesicle trafficking
ASJC Scopus subject areas
- General Neuroscience
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology