Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Alexander C W Smith, Yonatan M. Kupchik, Michael D. Scofield, Cassandra Gipson-Reichardt, Armina Wiggins, Charles A. Thomas, Peter W. Kalivas

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)1655-1657
Number of pages3
JournalNature Neuroscience
Volume17
Issue number12
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Neuronal Plasticity
Matrix Metalloproteinases
Cocaine
Recurrence
Cues
Extracellular Matrix Proteins
Matrix Metalloproteinase 2
Heroin
Matrix Metalloproteinase 9
Nucleus Accumbens
Nicotine
Synapses

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Smith, A. C. W., Kupchik, Y. M., Scofield, M. D., Gipson-Reichardt, C., Wiggins, A., Thomas, C. A., & Kalivas, P. W. (2014). Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. Nature Neuroscience, 17(12), 1655-1657. https://doi.org/10.1038/nn.3846

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. / Smith, Alexander C W; Kupchik, Yonatan M.; Scofield, Michael D.; Gipson-Reichardt, Cassandra; Wiggins, Armina; Thomas, Charles A.; Kalivas, Peter W.

In: Nature Neuroscience, Vol. 17, No. 12, 01.01.2014, p. 1655-1657.

Research output: Contribution to journalArticle

Smith, ACW, Kupchik, YM, Scofield, MD, Gipson-Reichardt, C, Wiggins, A, Thomas, CA & Kalivas, PW 2014, 'Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases', Nature Neuroscience, vol. 17, no. 12, pp. 1655-1657. https://doi.org/10.1038/nn.3846
Smith, Alexander C W ; Kupchik, Yonatan M. ; Scofield, Michael D. ; Gipson-Reichardt, Cassandra ; Wiggins, Armina ; Thomas, Charles A. ; Kalivas, Peter W. / Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. In: Nature Neuroscience. 2014 ; Vol. 17, No. 12. pp. 1655-1657.
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