Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10

Raymond S. Yeung, Kenneth Buetow, Joseph R. Testa, Alfred G. Knudson

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC) results in multiple chromophobe cell tumors that resemble the human disease, and heterozygous carriers (RC/+) are highly susceptible to environmental agents (radiation and chemical carcinogens), making it a desirable model to study epithelial carcinogenesis. By linkage analysis, the locus of the inherited RC mutation was mapped to rat chromosomal band 10q12, near the protamine locus (logarithm of odds score = 17.96). Renal tumors also showed a loss of heterozygosity at this locus, lending support to the recessive nature of this putative tumor suppressor gene. Our result suggested that the human homolog of the RC gene may reside on human chromosome 16, not known to be altered commonly in human RC.

Original languageEnglish (US)
Pages (from-to)8038-8042
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number17
StatePublished - Sep 1 1993
Externally publishedYes

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Chromosomes, Human, Pair 10
Tumor Suppressor Genes
Carcinoma
Kidney
Chromosomes, Human, Pair 16
Neoplasms
Protamines
Germ-Line Mutation
Loss of Heterozygosity
Human Chromosomes
Carcinogens
Carcinogenesis
Radiation
Mutation
Genes

Keywords

  • Animal model
  • Cytogenetic analysis
  • Hereditary cancer
  • Linkage analysis
  • Loss of heterozygosity

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10. / Yeung, Raymond S.; Buetow, Kenneth; Testa, Joseph R.; Knudson, Alfred G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 17, 01.09.1993, p. 8038-8042.

Research output: Contribution to journalArticle

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