TY - JOUR
T1 - Surface tension-controlled three-dimensional water molds
T2 - Theory and applications
AU - Goff, Chandra M.
AU - Chao, Shih-Hui
AU - Johnson, Roger H.
AU - Meldrum, Deirdre
N1 - Funding Information:
Acknowledgments The authors gratefully acknowledge support from the National Human Genome Research Institute Grant No. 1
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/12
Y1 - 2012/12
N2 - This paper presents a lab-on-a-chip development method that applies the Young-Laplace equation to design the geometries of a patterned water droplet, and then using the droplet as a mold to fabricate three-dimensional polydimethylsiloxane (PDMS) channels. We demonstrate the method by designing and fabricating an on-chip funnel. We then subsequently trap beads of graded diameter in the tapered section of the funnel to make on-chip filters of controllable pore size. After packing the funnel with beads, the cutoff pore size of the fabricated filter agrees closely with our estimate. This approach provides a straight-forward, low-cost, yet powerful way to design and fabricate microfluidic devices with 3D features.
AB - This paper presents a lab-on-a-chip development method that applies the Young-Laplace equation to design the geometries of a patterned water droplet, and then using the droplet as a mold to fabricate three-dimensional polydimethylsiloxane (PDMS) channels. We demonstrate the method by designing and fabricating an on-chip funnel. We then subsequently trap beads of graded diameter in the tapered section of the funnel to make on-chip filters of controllable pore size. After packing the funnel with beads, the cutoff pore size of the fabricated filter agrees closely with our estimate. This approach provides a straight-forward, low-cost, yet powerful way to design and fabricate microfluidic devices with 3D features.
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U2 - 10.1007/s10404-012-0997-4
DO - 10.1007/s10404-012-0997-4
M3 - Article
AN - SCOPUS:84871761633
SN - 1613-4982
VL - 13
SP - 891
EP - 897
JO - Microfluidics and Nanofluidics
JF - Microfluidics and Nanofluidics
IS - 6
ER -