Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging

Xiao Li Zhou, Yunze Yang, Shaopeng Wang, Xian Wei Liu

Research output: Contribution to journalReview article


Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single-molecule sensing to single-cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.

Original languageEnglish (US)
Pages (from-to)1776-1785
Number of pages10
JournalAngewandte Chemie - International Edition
Issue number5
StatePublished - Jan 27 2020
Externally publishedYes



  • binding kinetics
  • label-free methods
  • sensors
  • single-cell imaging
  • surface plasmon resonance

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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