Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging

Xiao Li Zhou; Yunze Yang; Shaopeng Wang; Xian Wei Liu

doi:10.1002/anie.201908806

Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging

Xiao Li Zhou, Yunze Yang, Shaopeng Wang, Xian Wei Liu

Engineering, Ira A. Fulton Schools of (IAFSE)

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single-molecule sensing to single-cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.

Original language	English (US)
Pages (from-to)	1776-1785
Number of pages	10
Journal	Angewandte Chemie - International Edition
Volume	59
Issue number	5
DOIs	https://doi.org/10.1002/anie.201908806
State	Published - Jan 27 2020

Keywords

binding kinetics
label-free methods
sensors
single-cell imaging
surface plasmon resonance

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201908806

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title = "Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging",

abstract = "Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single-molecule sensing to single-cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.",

keywords = "binding kinetics, label-free methods, sensors, single-cell imaging, surface plasmon resonance",

author = "Zhou, {Xiao Li} and Yunze Yang and Shaopeng Wang and Liu, {Xian Wei}",

note = "Funding Information: We thank the National Natural Science Foundation of China (NSFC 21676260, 51722810, 21707134, and 51821006), the China Postdoctoral Science Foundation (Grant No. 2017M610384), and the Recruitment Program for Young Professionals for support. S.W. acknowledges financial support from the National Institute of Health (2R01GM107165, R44GM126720, and R44GM114951). Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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doi = "10.1002/anie.201908806",

language = "English (US)",

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journal = "Angewandte Chemie - International Edition",

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AU - Zhou, Xiao Li

AU - Yang, Yunze

AU - Wang, Shaopeng

AU - Liu, Xian Wei

N1 - Funding Information: We thank the National Natural Science Foundation of China (NSFC 21676260, 51722810, 21707134, and 51821006), the China Postdoctoral Science Foundation (Grant No. 2017M610384), and the Recruitment Program for Young Professionals for support. S.W. acknowledges financial support from the National Institute of Health (2R01GM107165, R44GM126720, and R44GM114951). Publisher Copyright: © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2020/1/27

Y1 - 2020/1/27

N2 - Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single-molecule sensing to single-cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.

AB - Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single-molecule sensing to single-cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.

KW - binding kinetics

KW - label-free methods

KW - sensors

KW - single-cell imaging

KW - surface plasmon resonance

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DO - 10.1002/anie.201908806

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Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging

Abstract

Keywords

ASJC Scopus subject areas

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