Surface plasmon resonance mass spectrometry

Recent progress and outlooks

Dobrin Nedelkov, Randall W. Nelson

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The combination of surface plasmon resonance (SPR) and mass spectrometry (MS) has created a unique approach to protein investigations. Surface plasmon resonance is used to quantify interactions between proteins and surface-immobilized ligands, and MS is used to determine the structural features of the bound proteins. Recent progress in SPR-MS includes improved methods and operations, increased limits of detection, multi-protein analysis and protein-complex delineation. With the subsequent design of SPR protein arrays, SPR-MS is expected to enter into the field of high-throughput protein interaction discovery and miniaturized diagnostics.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalTrends in Biotechnology
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2003

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Surface Plasmon Resonance
Surface plasmon resonance
Mass spectrometry
Mass Spectrometry
Proteins
Immobilized Proteins
Protein Array Analysis
Limit of Detection
Membrane Proteins
Throughput
Ligands

ASJC Scopus subject areas

  • Bioengineering

Cite this

Surface plasmon resonance mass spectrometry : Recent progress and outlooks. / Nedelkov, Dobrin; Nelson, Randall W.

In: Trends in Biotechnology, Vol. 21, No. 7, 01.07.2003, p. 301-305.

Research output: Contribution to journalArticle

Nedelkov, Dobrin ; Nelson, Randall W. / Surface plasmon resonance mass spectrometry : Recent progress and outlooks. In: Trends in Biotechnology. 2003 ; Vol. 21, No. 7. pp. 301-305.
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