Surface fluid registration and multivariate tensor-based morphometry in newborns - The effects of prematurity on the putamen

Jie Shi, Yalin Wang, Rafael Ceschin, Xing An, Marvin D. Nelson, Ashok Panigrahy, Natasha Leporé

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Many disorders that affect the brain can cause shape changes in subcortical structures, and these may provide biomarkers for disease detection and progression. Automatic tools are needed to accurately identify and characterize these alterations. In recent work, we developed a surface multivariate tensor-based morphometry analysis (mTBM) to detect morphological group differences in subcortical structures, and we applied this method to study HIV/AIDS, William's syndrome, Alzheimer's disease and prematurity. Here we will focus more specifically on mTBM in neonates, which, in its current form, starts with manually segmented subcortical structures from MRI images of a two subject groups, places a conformal grid on each of their surfaces, registers them to a template through a constrained harmonic map and provides statistical comparisons between the two groups, at each vertex of the template grid. We improve this pipeline in two ways: first by replacing the constrained harmonic map with a new fluid registration algorithm that we recently developed. Secondly, by optimizing the pipeline to study the putamen in newborns.

Original languageEnglish (US)
Title of host publication2012 Conference Handbook - Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2012
StatePublished - Dec 1 2012
Event2012 4th Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2012 - Hollywood, CA, United States
Duration: Dec 3 2012Dec 6 2012

Publication series

Name2012 Conference Handbook - Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2012

Other

Other2012 4th Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2012
CountryUnited States
CityHollywood, CA
Period12/3/1212/6/12

ASJC Scopus subject areas

  • Information Systems

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    Shi, J., Wang, Y., Ceschin, R., An, X., Nelson, M. D., Panigrahy, A., & Leporé, N. (2012). Surface fluid registration and multivariate tensor-based morphometry in newborns - The effects of prematurity on the putamen. In 2012 Conference Handbook - Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2012 [6411997] (2012 Conference Handbook - Asia-Pacific Signal and Information Processing Association Annual Summit and Conference, APSIPA ASC 2012).